Transactions
| Date | Player | Transactions |
| 1/12 | Jon Lester, P | Retired |
| 11/30 | José Rondón, SS | Free Agent - No Contract Offer (non-tendered) |
| 11/29 | Steven Matz, P | Signed as Free Agent ( 2022-2025)(four-year contract) |
| 11/19 | Brendan Donovan, 2B | Purchased From Minors |
| 11/19 | Freddy Pacheco, P | Purchased From Minors |
| 11/19 | Kyle Ryan, P | Signed to a Minor League Contract |
| 11/19 | Jake Walsh, P | Purchased From Minors |
| 11/18 | Ljay Newsome, P | Outrighted to Minors |
| 11/18 | Anderson Tejeda, SS | Signed to a Minor League Contract |
| 11/9 | Nick Plummer, CF | Declared Free Agency |
| 11/9 | Justin Williams, RF | Refused Minor League Assignment - Free Agent |
| 11/8 | T.J. McFarland, P | Signed as Free Agent ( 2022)(one-year contract) |
| 11/7 | Brett Cecil, P | Retired |
| 11/5 | Max Moroff, 2B | Outrighted to Minors |
| 11/5 | Max Moroff, 2B | Refused Minor League Assignment - Free Agent |
| 11/5 | Justin Williams, RF | Outrighted to Minors |
| 11/4 | Matt Carpenter, 3B | Declared Free Agency (team option declined) |
| 11/4 | Carlos Martínez, P | Declared Free Agency (team option declined) |
| 11/3 | Junior Fernández, P | Removed From 60-Day IL (Torn right lat - out for season) |
| 11/3 | Luís García, P | Declared Free Agency |
| 11/3 | J.A. Happ, P | Declared Free Agency |
| 11/3 | Ryan Helsley, P | Removed From 60-Day IL (Right elbow stress reaction) |
| 11/3 | Kwang Hyun Kim, P | Declared Free Agency |
| 11/3 | Wade LeBlanc, P | Declared Free Agency |
| 11/3 | Jon Lester, P | Declared Free Agency |
| 11/3 | Carlos Martínez, P | Removed From 60-Day IL (Torn ligament, right thumb) |
| 11/3 | T.J. McFarland, P | Declared Free Agency |
| 11/3 | Andrew Miller, P | Declared Free Agency |
| 11/3 | Max Moroff, 2B | Removed From 60-Day IL (Left shoulder surgery - out for season) |
| 11/3 | Ljay Newsome, P | Removed From 60-Day IL (Right elbow inflammation) |
| 10/28 | Justin Miller, P | Refused Minor League Assignment - Free Agent |
| 10/27 | Justin Miller, P | Outrighted to Minors |
| 10/25 | Jordan Hicks, P | Removed From 60-Day IL (Right elbow inflammation) |
| 10/25 | Justin Miller, P | Designated for Assignment |
| 10/24 | Jordan Hicks, P | Recalled From Minors Rehab Assignment |
| 10/22 | Ljay Newsome, P | Acquired Off Waivers Seattle |
| 10/14 | Tyler Webb, P | Refused Minor League Assignment - Free Agent |
| 10/8 | Seth Elledge, P | Outrighted to Minors |
| 10/8 | Justin Miller, P | Removed From 10-Day IL (Right elbow strain) |
| 10/6 | Seth Elledge, P | Designated for Assignment |
| 10/6 | Juan Yepez, 1B | Purchased From Minors |
| 10/4 | Austin Dean, RF | Called Up from Minors |
| 10/4 | Seth Elledge, P | Called Up from Minors |
| 10/4 | Iván Herrera, C | Called Up from Minors |
| 10/4 | Wade LeBlanc, P | Removed From 10-Day IL (Left elbow injury) |
| 10/4 | Johan Oviedo, P | Called Up from Minors |
| 10/4 | Johan Quezada, P | Called Up from Minors |
| 10/4 | Angel Rondón, P | Called Up from Minors |
| 10/4 | Ali Sánchez, C | Called Up from Minors |
| 10/4 | Brandon Waddell, P | Called Up from Minors |
| 10/4 | Justin Williams, RF | Called Up from Minors |
| 10/4 | T.J. Zeuch, P | Called Up from Minors |
| 10/1 | Adam Wainwright, P | Signed ( 2022)(one-year extension) |
Last updated Jan. 27, 1:27 A.M. ET
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