Transactions
| Date | Player | Transactions |
| 8/1 | Jake Woodford, P | Sent to Minors |
| 7/30 | J.A. Happ, P | Traded Minnesota (for RHP John Gant and LHP Evan Sisk) |
| 7/30 | Jon Lester, P | Traded Washington (for OF Lane Thomas) |
| 7/30 | Lars Nootbaar, RF | Called Up from Minors |
| 7/27 | Jack Flaherty, P | Sent to Minors For Rehabilitation |
| 7/27 | Lane Thomas, CF | Called Up from Minors |
| 7/26 | Johan Oviedo, P | Sent to Minors |
| 7/25 | T.J. Zeuch, P | Traded Toronto (for cash considerations) |
| 7/25 | T.J. Zeuch, P | Sent to Minors |
| 7/24 | Miles Mikolas, P | Sent to Minors For Rehabilitation |
| 7/22 | Daniel Ponce de Leon, P | Sent to Minors For Rehabilitation |
| 7/20 | Junior Fernández, P | Sent to Minors |
| 7/20 | Johan Oviedo, P | Called Up from Minors |
| 7/19 | Jake Woodford, P | Called Up from Minors |
| 7/18 | Lars Nootbaar, RF | Sent to Minors |
| 7/16 | T.J. McFarland, P | Purchased From Minors |
| 7/16 | Brandon Waddell, P | Sent to Minors |
| 7/11 | Kodi Whitley, P | Recalled From Minors Rehab Assignment |
| 7/11 | Kodi Whitley, P | Removed From 10-Day IL (Back spasms) |
| 7/11 | Kodi Whitley, P | Sent to Minors |
| 7/9 | Luís García, P | Signed as Free Agent ( 2021)(one-year contract) |
| 7/9 | Carlos Martínez, P | Transferred to 60-Day IL (Torn ligament, right thumb) |
| 7/8 | Johan Oviedo, P | Sent to Minors |
| 7/7 | Carlos Martínez, P | Placed on 10-Day IL (Torn ligament, right thumb) |
| 7/7 | Lars Nootbaar, RF | Called Up from Minors |
| 7/3 | Roel Ramírez, P | Sent to Minors |
| 7/2 | Jack Flaherty, P | Transferred to 60-Day IL (Strained left oblique) |
| 7/2 | Justin Miller, P | Acquired Off Waivers Washington |
| 7/1 | Harrison Bader, CF | Recalled From Minors Rehab Assignment |
| 7/1 | Harrison Bader, CF | Removed From 10-Day IL (Right rib hairline fracture) |
| 7/1 | Tyler Heineman, C | Released |
| 7/1 | Lars Nootbaar, RF | Sent to Minors |
| 6/30 | T.J. McFarland, P | Signed to a Minor League Contract |
| 6/28 | Seth Elledge, P | Sent to Minors |
| 6/28 | John Nogowski, 1B | Designated for Assignment |
| 6/28 | Roel Ramírez, P | Purchased From Minors |
| 6/28 | Matt Szczur, LF | Released |
| 6/28 | Brandon Waddell, P | Called Up from Minors |
| 6/28 | Jake Woodford, P | Sent to Minors |
| 6/26 | Kodi Whitley, P | Sent to Minors For Rehabilitation |
| 6/25 | Harrison Bader, CF | Sent to Minors For Rehabilitation |
| 6/23 | Seth Elledge, P | Called Up from Minors |
| 6/23 | Daniel Ponce de Leon, P | Placed on 10-Day IL (Right shoulder discomfort) |
| 6/22 | Bernardo Flores Jr., P | Designated for Assignment |
| 6/22 | Lars Nootbaar, RF | Purchased From Minors |
| 6/22 | Lane Thomas, CF | Sent to Minors |
| 6/18 | Justin Williams, RF | Recalled From Minors Rehab Assignment |
| 6/18 | Justin Williams, RF | Removed From 10-Day IL (Neck stiffness) |
| 6/18 | Justin Williams, RF | Sent to Minors |
| 6/17 | Brandon Dickson, P | Signed to a Minor League Contract |
| 6/17 | Wade LeBlanc, P | Signed as Free Agent ( 2021)(one-year contract) |
| 6/17 | Max Moroff, 2B | Transferred to 60-Day IL (Left shoulder surgery - out for season) |
| 6/16 | Seth Elledge, P | Sent to Minors |
| 6/15 | Kwang Hyun Kim, P | Removed From 10-Day IL (Right lower back stiffness) |
| 6/15 | Angel Rondón, P | Sent to Minors |
| 6/11 | Paul DeJong, SS | Recalled From Minors Rehab Assignment |
| 6/11 | Paul DeJong, SS | Removed From 10-Day IL (Left rib non-displaced fracture) |
| 6/11 | Justin Williams, RF | Sent to Minors For Rehabilitation |
| 6/10 | John Nogowski, 1B | Sent to Minors |
| 6/6 | Brandon Waddell, P | Acquired Off Waivers Baltimore |
| 6/6 | Brandon Waddell, P | Sent to Minors |
| 6/6 | Tyler Webb, P | Outrighted to Minors |
| 6/5 | Paul DeJong, SS | Sent to Minors For Rehabilitation |
| 6/5 | Kwang Hyun Kim, P | Placed on 10-Day IL (Right lower back stiffness) |
| 6/5 | John Nogowski, 1B | Called Up from Minors |
| 6/5 | Angel Rondón, P | Called Up from Minors |
| 6/5 | Justin Williams, RF | Placed on 10-Day IL (Neck stiffness) |
| 6/3 | Andrew Miller, P | Recalled From Minors Rehab Assignment |
| 6/3 | Andrew Miller, P | Removed From 10-Day IL (Toe blister, right foot) |
| 6/3 | Tyler Webb, P | Designated for Assignment |
| 6/1 | Jack Flaherty, P | Placed on 10-Day IL (Strained left oblique) |
| 6/1 | Johan Oviedo, P | Called Up from Minors |
| 5/30 | Seth Elledge, P | Called Up from Minors |
| 5/30 | Kodi Whitley, P | Placed on 10-Day IL (Back spasms) |
| 5/29 | Junior Fernández, P | Called Up from Minors |
| 5/29 | Miles Mikolas, P | Transferred to 60-Day IL (Right forearm tightness) |
| 5/29 | Max Moroff, 2B | Placed on 10-Day IL (Left shoulder surgery - out for season) |
| 5/29 | Johan Oviedo, P | Sent to Minors |
| 5/29 | José Rondón, SS | Purchased From Minors |
| 5/28 | Junior Fernández, P | Sent to Minors |
| 5/28 | Johan Oviedo, P | Called Up from Minors |
| 5/27 | Tyler O'Neill, RF | Removed From 10-Day IL (Fractured left middle finger) |
| 5/26 | John Nogowski, 1B | Sent to Minors |
| 5/25 | Harrison Bader, CF | Placed on 10-Day IL (Right rib hairline fracture) |
| 5/25 | Andrew Miller, P | Sent to Minors For Rehabilitation |
| 5/25 | John Nogowski, 1B | Called Up from Minors |
| 5/23 | Junior Fernández, P | Called Up from Minors |
| 5/23 | Miles Mikolas, P | Placed on 10-Day IL (Right forearm tightness) |
| 5/22 | Miles Mikolas, P | Recalled From Minors Rehab Assignment |
| 5/22 | Miles Mikolas, P | Removed From 10-Day IL (Recovery from right forearm surgery) |
| 5/21 | Seth Elledge, P | Sent to Minors |
| 5/21 | Carlos Martínez, P | Removed From 10-Day IL (Sprained right ankle) |
| 5/19 | John Nogowski, 1B | Sent to Minors |
| 5/18 | Junior Fernández, P | Sent to Minors |
| 5/18 | John Nogowski, 1B | Recalled From Minors Rehab Assignment |
| 5/18 | John Nogowski, 1B | Removed From 10-Day IL (Bone bruise, left hand) |
| 5/18 | Tyler O'Neill, RF | Placed on 10-Day IL (Fractured left middle finger) |
| 5/18 | Daniel Ponce de Leon, P | Recalled From Minors Rehab Assignment |
| 5/18 | Daniel Ponce de Leon, P | Removed From 10-Day IL (Right shoulder inflammation) |
| 5/15 | Junior Fernández, P | Called Up from Minors |
| 5/15 | Johan Oviedo, P | Sent to Minors |
| 5/14 | Paul DeJong, SS | Placed on 10-Day IL (Left rib non-displaced fracture) |
| 5/14 | Jordan Hicks, P | Transferred to 60-Day IL (Right elbow inflammation) |
| 5/14 | Max Moroff, 2B | Purchased From Minors |
| 5/13 | Daniel Ponce de Leon, P | Sent to Minors For Rehabilitation |
| 5/11 | Carlos Martínez, P | Placed on 10-Day IL (Sprained right ankle) |
| 5/11 | Johan Oviedo, P | Called Up from Minors |
| 5/8 | Yadier Molina, C | Removed From 10-Day IL (Right foot tendon strain) |
| 5/8 | Ali Sánchez, C | Sent to Minors |
| 5/7 | John Nogowski, 1B | Sent to Minors For Rehabilitation |
| 5/6 | Lane Thomas, CF | Called Up from Minors |
| 5/5 | Bernardo Flores Jr., P | Called Up from Minors (recalled as 27th roster player) |
| 5/5 | Bernardo Flores Jr., P | Return of 27th man |
| 5/5 | Miles Mikolas, P | Sent to Minors For Rehabilitation |
| 5/5 | Johan Oviedo, P | Sent to Minors |
| 5/4 | Jordan Hicks, P | Placed on 10-Day IL (Right elbow inflammation) |
| 5/4 | Johan Oviedo, P | Called Up from Minors |
| 5/3 | Austin Dean, RF | Sent to Minors |
| 5/3 | Adam Wainwright, P | Removed From 10-Day IL (COVID-19 injured list (exposure)) |
| 4/30 | Harrison Bader, CF | Removed From 10-Day IL (Strained right forearm) |
| 4/30 | Andrew Miller, P | Placed on 10-Day IL (Toe blister, right foot) |
| 4/30 | Daniel Ponce de Leon, P | Placed on 10-Day IL (Right shoulder inflammation) |
| 4/30 | Kodi Whitley, P | Called Up from Minors |
| 4/30 | Jake Woodford, P | Called Up from Minors |
| 4/29 | Seth Elledge, P | Called Up from Minors |
| 4/29 | Adam Wainwright, P | Placed on 10-Day IL (COVID-19 injured list (exposure)) |
| 4/28 | Scott Hurst, CF | Sent to Minors |
| 4/28 | Johan Oviedo, P | Called Up from Minors |
| 4/28 | Johan Oviedo, P | Sent to Minors |
| 4/27 | Yadier Molina, C | Placed on 10-Day IL (Right foot tendon strain) |
| 4/27 | Ali Sánchez, C | Called Up from Minors |
| 4/23 | John Nogowski, 1B | Placed on 10-Day IL (Bone bruise, left hand) |
| 4/23 | Tyler O'Neill, RF | Removed From 10-Day IL (Right groin strain) |
| 4/17 | Kwang Hyun Kim, P | Removed From 10-Day IL (Lower back tightness) |
| 4/17 | Kodi Whitley, P | Sent to Minors |
| 4/15 | Dakota Hudson, P | Transferred to 60-Day IL (Recovery from right elbow surgery) |
| 4/15 | Scott Hurst, CF | Purchased From Minors |
| 4/15 | Lane Thomas, CF | Sent to Minors |
| 4/13 | Kodi Whitley, P | Called Up from Minors |
| 4/12 | Johan Oviedo, P | Sent to Minors |
| 4/11 | Tyler O'Neill, RF | Placed on 10-Day IL (Right groin strain) |
| 4/11 | Johan Oviedo, P | Called Up from Minors |
| 4/11 | Lane Thomas, CF | Called Up from Minors |
| 4/10 | Jake Woodford, P | Sent to Minors |
| 4/1 | Harrison Bader, CF | Placed on 10-Day IL (Strained right forearm) |
| 4/1 | Bernardo Flores Jr., P | Acquired Off Waivers Chi. White Sox |
| 4/1 | Bernardo Flores Jr., P | Sent to Minors |
| 4/1 | Dakota Hudson, P | Placed on 10-Day IL (Recovery from right elbow surgery) |
| 4/1 | Kwang Hyun Kim, P | Placed on 10-Day IL (Lower back tightness) |
| 4/1 | Miles Mikolas, P | Placed on 10-Day IL (Recovery from right forearm surgery) |
| 3/30 | Akeem Bostick, P | Released |
| 3/28 | Lane Thomas, CF | Sent to Minors |
| 3/28 | Kodi Whitley, P | Sent to Minors |
| 3/25 | Johan Oviedo, P | Sent to Minors |
| 3/20 | Seth Elledge, P | Sent to Minors |
| 3/20 | Iván Herrera, C | Sent to Minors |
| 3/20 | Angel Rondón, P | Sent to Minors |
| 3/20 | Ali Sánchez, C | Sent to Minors |
| 3/13 | Junior Fernández, P | Sent to Minors |
| 3/13 | Johan Quezada, P | Sent to Minors |
| 2/13 | Jack Flaherty, P | Signed ( 2021)(wins arbitration) |
| 2/13 | Matt Szczur, LF | Signed to a Minor League Contract |
| 2/12 | Ali Sánchez, C | Traded NY Mets (for cash considerations) |
| 2/10 | Johan Quezada, P | Traded Philadelphia (for cash considerations) |
| 2/9 | Yadier Molina, C | Signed as Free Agent ( 2021)(one-year contract) |
| 2/1 | Nolan Arenado, 3B | Traded Colorado (for LHP Austin Gomber, six-player trade) |
| 1/29 | Adam Wainwright, P | Signed as Free Agent ( 2021)(one-year contract) |
| 1/15 | Harrison Bader, CF | Signed ( 2021)(avoids arbitration) |
| 1/15 | Jordan Hicks, P | Signed ( 2021)(avoids arbitration) |
| 1/15 | Alex Reyes, P | Signed ( 2021)(avoids arbitration) |
| 12/18 | José Rondón, SS | Signed to a Minor League Contract |
| 12/15 | Max Moroff, 2B | Signed to a Minor League Contract |
| 12/3 | John Gant, P | Signed ( 2021)(avoids arbitration) |
| 12/2 | John Brebbia, P | Free Agent - No Contract Offer (non-tendered) |
| 12/2 | Rangel Ravelo, 1B | Free Agent - No Contract Offer (non-tendered) |
| 11/19 | Angel Rondón, P | Purchased From Minors |
| 11/18 | Iván Herrera, C | Purchased From Minors |
| 11/13 | Tyler Heineman, C | Signed to a Minor League Contract |
| 11/2 | Nabil Crismatt, P | Declared Free Agency |
| 10/30 | John Brebbia, P | Removed From 60-Day IL (Right elbow surgery - out for season) |
| 10/30 | Nabil Crismatt, P | Outrighted to Minors |
| 10/30 | Jordan Hicks, P | Removed From 60-Day IL (Recovery from right elbow surgery) |
| 10/30 | Dakota Hudson, P | Removed From 60-Day IL (Right elbow surgery - out for season) |
| 10/30 | Miles Mikolas, P | Removed From 60-Day IL (Right forearm surgery - out for season) |
| 10/30 | Ricardo Sánchez, P | Removed From 60-Day IL (Left elbow pain) |
| 10/30 | Ricardo Sánchez, P | Outrighted to Minors |
| 10/28 | Brad Miller, 2B | Declared Free Agency |
| 10/28 | Yadier Molina, C | Declared Free Agency |
| 10/28 | Adam Wainwright, P | Declared Free Agency |
| 10/28 | Matt Wieters, C | Declared Free Agency |
| 10/28 | Kolten Wong, 2B | Declared Free Agency (team option declined) |
| 10/5 | Ryan Meisinger, P | Refused Minor League Assignment - Free Agent |
Last updated Aug. 3, 10:43 P.M. ET
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