Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Yadier Molina | Andrew Knizner | ||||
| First Base | Paul Goldschmidt | |||||
| Second Base | Tommy Edman | Matt Carpenter | ||||
| Shortstop | Paul DeJong | Edmundo Sosa | ||||
| Third Base | Nolan Arenado | |||||
| Left Field | Tyler O'Neill | Lane Thomas | ||||
| Center Field | Harrison Bader | |||||
| Right Field | Dylan Carlson | Justin Williams | ||||
| Starting Pitcher | Jack Flaherty | Adam Wainwright | Johan Oviedo | Kwang Hyun Kim | John Gant | |
| Closer | Alex Reyes | |||||
| Relief Pitcher | Giovanny Gallegos | Ryan Helsley | Génesis Cabrera | Tyler Webb | Jake Woodford | Kodi Whitley |
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