Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Willson Contreras | Andrew Knizner | ||||
| First Base | Paul Goldschmidt | |||||
| Second Base | Brendan Donovan | Nolan Gorman | ||||
| Shortstop | Tommy Edman | Paul DeJong | ||||
| Third Base | Nolan Arenado | |||||
| Left Field | Tyler O'Neill | Moisés Gómez | ||||
| Center Field | Dylan Carlson | |||||
| Right Field | Lars Nootbaar | Alec Burleson | ||||
| Starting Pitcher | Adam Wainwright | Miles Mikolas | Jack Flaherty | Steven Matz | Jordan Montgomery | Matthew Liberatore |
| Closer | Ryan Helsley | |||||
| Relief Pitcher | Génesis Cabrera | Giovanny Gallegos | Jordan Hicks | Chris Stratton | Andre Pallante | Wilking Rodríguez |
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