Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Yadier Molina | Andrew Knizner | ||||
| First Base | Paul Goldschmidt | |||||
| Second Base | Tommy Edman | Juan Yepez | ||||
| Shortstop | Edmundo Sosa | Paul DeJong | ||||
| Third Base | Nolan Arenado | |||||
| Left Field | Tyler O'Neill | |||||
| Center Field | Harrison Bader | |||||
| Right Field | Dylan Carlson | Lars Nootbaar | ||||
| Starting Pitcher | Adam Wainwright | Miles Mikolas | Jack Flaherty | Steven Matz | Dakota Hudson | |
| Closer | Alex Reyes | |||||
| Relief Pitcher | Giovanny Gallegos | Génesis Cabrera | Jake Woodford | Jordan Hicks | T.J. McFarland | Ryan Helsley |
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