Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Tucker Barnhart | Curt Casali | ||||
| First Base | Joey Votto | |||||
| Second Base | Mike Moustakas | Alex Blandino | ||||
| Shortstop | Freddy Galvis | |||||
| Third Base | Eugenio Suárez | Josh VanMeter | ||||
| Left Field | Jesse Winker | Phillip Ervin | ||||
| Center Field | Shogo Akiyama | Nick Senzel | ||||
| Right Field | Nick Castellanos | Aristides Aquino | ||||
| Starting Pitcher | Luis Castillo | Trevor Bauer | Sonny Gray | Wade Miley | Anthony DeSclafani | Tyler Mahle |
| Closer | Raisel Iglesias | |||||
| Relief Pitcher | Robert Stephenson | Michael Lorenzen | Pedro Strop | Amir Garrett | José De León | Cody Reed |
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