Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Willson Contreras | Yan Gomes | ||||
| First Base | Frank Schwindel | |||||
| Second Base | Sergio Alcántara | Nick Madrigal | ||||
| Shortstop | Nico Hoerner | |||||
| Third Base | Patrick Wisdom | David Bote | ||||
| Left Field | Clint Frazier | Harold Ramirez | ||||
| Center Field | Ian Happ | Michael Hermosillo | ||||
| Right Field | Jason Heyward | Rafael Ortega | ||||
| Starting Pitcher | Kyle Hendricks | Marcus Stroman | Adbert Alzolay | Wade Miley | Alec Mills | Justin Steele |
| Closer | Rowan Wick | |||||
| Relief Pitcher | Codi Heuer | Brad Wieck | Michael Rucker | Manuel Rodríguez | Tommy Nance | Keegan Thompson |
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