Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Willson Contreras | |||||
| First Base | Anthony Rizzo | |||||
| Second Base | David Bote | Ildemaro Vargas | ||||
| Shortstop | Javier Báez | Nico Hoerner | ||||
| Third Base | Kris Bryant | Max Schrock | ||||
| Left Field | Phillip Ervin | |||||
| Center Field | Ian Happ | |||||
| Right Field | Jason Heyward | |||||
| Starting Pitcher | Kyle Hendricks | Alec Mills | Zach Davies | Adbert Alzolay | James Norwood | Colin Rea |
| Closer | Craig Kimbrel | |||||
| Relief Pitcher | Rowan Wick | Kyle Ryan | Jason Adam | Brad Wieck | Dan Winkler | Duane Underwood Jr. |
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