Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Willson Contreras | Victor Caratini | ||||
| First Base | Anthony Rizzo | |||||
| Second Base | David Bote | |||||
| Shortstop | Javier Báez | Nico Hoerner | ||||
| Third Base | Kris Bryant | Daniel Descalso | ||||
| Left Field | Kyle Schwarber | |||||
| Center Field | Ian Happ | Albert Almora Jr. | ||||
| Right Field | Jason Heyward | Steven Souza Jr. | ||||
| Starting Pitcher | Yu Darvish | José Quintana | Kyle Hendricks | Jon Lester | Tyler Chatwood | Jharel Cotton |
| Closer | Craig Kimbrel | |||||
| Relief Pitcher | Kyle Ryan | Rowan Wick | Jeremy Jeffress | Brad Wieck | Ryan Tepera | Casey Sadler |
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