Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Danny Jansen | Reese McGuire | ||||
| First Base | Vladimir Guerrero Jr. | |||||
| Second Base | Marcus Semien | Otto Lopez | ||||
| Shortstop | Bo Bichette | Santiago Espinal | ||||
| Third Base | Cavan Biggio | |||||
| Left Field | Lourdes Gurriel Jr. | |||||
| Center Field | George Springer | Randal Grichuk | ||||
| Right Field | Teoscar Hernández | Jonathan Davis | ||||
| Designated Hitter | Rowdy Tellez | |||||
| Starting Pitcher | Hyun Jin Ryu | Robbie Ray | Tanner Roark | Steven Matz | Nate Pearson | Ross Stripling |
| Closer | Kirby Yates | |||||
| Relief Pitcher | Jordan Romano | Julian Merryweather | Rafael Dolis | Tyler Chatwood | Ryan Borucki | Anthony Kay |
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