Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Yasmani Grandal | James McCann | ||||
| First Base | José Abreu | Zack Collins | ||||
| Second Base | Danny Mendick | |||||
| Shortstop | Tim Anderson | |||||
| Third Base | Yoán Moncada | Yolmer Sánchez | ||||
| Left Field | Eloy Jiménez | |||||
| Center Field | Luis Robert | Jarrod Dyson | ||||
| Right Field | Nomar Mazara | Adam Engel | ||||
| Designated Hitter | Edwin Encarnación | |||||
| Starting Pitcher | Lucas Giolito | Dallas Keuchel | Dylan Cease | Dane Dunning | Gio González | |
| Closer | Alex Colomé | |||||
| Relief Pitcher | Steve Cishek | Evan Marshall | Matt Foster | Ross Detwiler | Jimmy Cordero | Codi Heuer |
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