Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Yasmani Grandal | Seby Zavala | ||||
| First Base | José Abreu | |||||
| Second Base | Josh Harrison | |||||
| Shortstop | Elvis Andrus | Romy González | ||||
| Third Base | Yoán Moncada | |||||
| Left Field | Eloy Jiménez | |||||
| Center Field | Luis Robert | Adam Engel | ||||
| Right Field | AJ Pollock | Gavin Sheets | ||||
| Designated Hitter | Andrew Vaughn | |||||
| Starting Pitcher | Lucas Giolito | Lance Lynn | Dylan Cease | Michael Kopech | Johnny Cueto | |
| Closer | Liam Hendriks | |||||
| Relief Pitcher | Joe Kelly | Kendall Graveman | Jake Diekman | Matt Foster | José Ruiz | Jimmy Lambert |
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