Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Zack Collins | Seby Zavala | ||||
| First Base | José Abreu | |||||
| Second Base | Danny Mendick | Leury García | ||||
| Shortstop | Tim Anderson | |||||
| Third Base | Yoán Moncada | |||||
| Left Field | Andrew Vaughn | |||||
| Center Field | Brian Goodwin | Billy Hamilton | ||||
| Right Field | Gavin Sheets | |||||
| Designated Hitter | Gavin Sheets | |||||
| Starting Pitcher | Lucas Giolito | Lance Lynn | Carlos Rodón | Dylan Cease | Dallas Keuchel | |
| Closer | Liam Hendriks | |||||
| Relief Pitcher | Ryan Burr | Michael Kopech | Codi Heuer | Garrett Crochet | Reynaldo López | José Ruiz |
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