Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Christian Vázquez | Sandy León | ||||
| First Base | Michael Chavis | |||||
| Second Base | Brock Holt | Eduardo Núñez | ||||
| Shortstop | Xander Bogaerts | Marco Hernández | ||||
| Third Base | Rafael Devers | |||||
| Left Field | Andrew Benintendi | Brock Holt | ||||
| Center Field | Jackie Bradley Jr. | |||||
| Right Field | Mookie Betts | |||||
| Designated Hitter | J.D. Martinez | |||||
| Starting Pitcher | Chris Sale | David Price | Rick Porcello | Andrew Cashner | Eduardo Rodriguez | |
| Closer | Ryan Brasier | |||||
| Relief Pitcher | Matt Barnes | Colten Brewer | Brandon Workman | Marcus Walden | Heath Hembree | Josh Taylor |
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