Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Christian Vázquez | Connor Wong | ||||
| First Base | Bobby Dalbec | |||||
| Second Base | Kiké Hernández | Marwin Gonzalez | ||||
| Shortstop | Xander Bogaerts | Christian Arroyo | ||||
| Third Base | Rafael Devers | |||||
| Left Field | Alex Verdugo | |||||
| Center Field | Danny Santana | Marwin Gonzalez | ||||
| Right Field | Hunter Renfroe | |||||
| Designated Hitter | J.D. Martinez | |||||
| Starting Pitcher | Nathan Eovaldi | Garrett Richards | Eduardo Rodriguez | Nick Pivetta | Martín Pérez | |
| Closer | Matt Barnes | |||||
| Relief Pitcher | Adam Ottavino | Darwinzon Hernandez | Hirokazu Sawamura | Garrett Whitlock | Brandon Workman | Josh Taylor |
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