Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Christian Vázquez | Kevin Plawecki | ||||
| First Base | Mitch Moreland | |||||
| Second Base | José Peraza | Michael Chavis | ||||
| Shortstop | Xander Bogaerts | Tzu-Wei Lin | ||||
| Third Base | Rafael Devers | |||||
| Left Field | Andrew Benintendi | |||||
| Center Field | Jackie Bradley Jr. | |||||
| Right Field | Kevin Pillar | Alex Verdugo | ||||
| Designated Hitter | J.D. Martinez | |||||
| Starting Pitcher | Eduardo Rodriguez | Nathan Eovaldi | Martín Pérez | Collin McHugh | Darwinzon Hernandez | Ryan Weber |
| Closer | Brandon Workman | |||||
| Relief Pitcher | Matt Barnes | Josh Taylor | Heath Hembree | Marcus Walden | Ryan Brasier | Austin Brice |
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