Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Christian Vázquez | Kevin Plawecki | ||||
| First Base | Bobby Dalbec | |||||
| Second Base | Christian Arroyo | Jonathan Araúz | ||||
| Shortstop | Xander Bogaerts | Jeter Downs | ||||
| Third Base | Rafael Devers | |||||
| Left Field | Alex Verdugo | |||||
| Center Field | Kiké Hernández | Jarren Duran | ||||
| Right Field | Jackie Bradley Jr. | |||||
| Designated Hitter | J.D. Martinez | |||||
| Starting Pitcher | Chris Sale | Nathan Eovaldi | Tanner Houck | Michael Wacha | Nick Pivetta | Darwinzon Hernandez |
| Closer | Matt Barnes | |||||
| Relief Pitcher | Garrett Whitlock | Austin Davis | Josh Taylor | Ryan Brasier | Hirokazu Sawamura | Phillips Valdéz |
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