Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Christian Vázquez | Sandy León | ||||
| First Base | Mitch Moreland | Sam Travis | ||||
| Second Base | Brock Holt | |||||
| Shortstop | Xander Bogaerts | Marco Hernández | ||||
| Third Base | Rafael Devers | |||||
| Left Field | Andrew Benintendi | Chris Owings | ||||
| Center Field | Jackie Bradley Jr. | Gorkys Hernández | ||||
| Right Field | Mookie Betts | |||||
| Designated Hitter | J.D. Martinez | |||||
| Starting Pitcher | Rick Porcello | David Price | Nathan Eovaldi | Eduardo Rodriguez | Jhoulys Chacín | |
| Closer | Brandon Workman | |||||
| Relief Pitcher | Darwinzon Hernandez | Matt Barnes | Hector Velázquez | Marcus Walden | Ryan Brasier | Andrew Cashner |
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