Depth Chart
| Offense | |||
| Position | |||
| Left Tackle | Joe Staley | Justin Skule | |
| Left Guard | Laken Tomlinson | Daniel Brunskill | |
| Center | Ben Garland | ||
| Right Guard | Mike Person | Daniel Brunskill | |
| Right Tackle | Mike McGlinchey | Daniel Brunskill | |
| Wide Receiver | Deebo Samuel | Kendrick Bourne | Dante Pettis |
| Wide Receiver | Emmanuel Sanders | Richie James Jr. | Jordan Matthews |
| Running Back | Raheem Mostert | Matt Breida | Tevin Coleman |
| Tight End | George Kittle | Ross Dwelley | Levine Toilolo |
| Quarterback | Jimmy Garoppolo | Nick Mullens | C.J. Beathard |
| Defense | |||
| Position | |||
| Left Defensive End | Arik Armstead | Dee Ford | |
| Left Defensive Tackle | Sheldon Day | Solomon Thomas | Earl Mitchell |
| Right Defensive Tackle | DeForest Buckner | Kevin Givens | |
| Right Defensive End | Nick Bosa | Anthony Zettel | |
| Strong Linebacker | Dre Greenlaw | Elijah Lee | |
| Middle Linebacker | Fred Warner | Azeez Al-Shaair | |
| Weak Linebacker | Kwon Alexander | Mark Nzeocha | |
| Left Cornerback | Richard Sherman | Dontae Johnson | |
| Right Cornerback | Ahkello Witherspoon | Emmanuel Moseley | |
| Strong Safety | Jaquiski Tartt | Marcell Harris | |
| Free Safety | Jimmie Ward | Tarvarius Moore | |
| Special Teams | |||
| Position | |||
| Kicker | Robbie Gould | ||
| Kick-Offs | Robbie Gould | ||
| Punter | Mitch Wishnowsky | ||
| Kick Returner | Richie James Jr. | D.J. Reed Jr. | Matt Breida |
| Punt Returner | Richie James Jr. | Dante Pettis | D.J. Reed Jr. |
| Holder | Mitch Wishnowsky | ||
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