NFL Leaders |
Passes Defensed
| Rank | Name | Team | G | TK | Sacks | Sack-Yds | Int | Fum | PD |
| 1 | S. Gilmore | NE | 16 | 53 | 0.0 | 0.0 | 6 | 0 | 20 |
| 2 | C. Davis III | TB | 14 | 59 | 0.0 | 0.0 | 1 | 1 | 19 |
| 3 | L. Ryan | Ten | 16 | 113 | 4.5 | 31.5 | 4 | 4 | 18 |
| 4t | J. Alexander | GB | 16 | 58 | 0.0 | 0.0 | 2 | 1 | 17 |
| 4t | J. Dean | TB | 13 | 21 | 0.0 | 0.0 | 2 | 0 | 17 |
| 4t | J. Haden | Pit | 16 | 65 | 0.0 | 0.0 | 5 | 1 | 17 |
| 4t | T. White | Buf | 15 | 58 | 1.0 | 9.0 | 6 | 2 | 17 |
| 8 | J. Jenkins | NO | 15 | 61 | 0.0 | 0.0 | 5 | 0 | 16 |
| 9t | K. King | GB | 15 | 66 | 1.0 | 2.0 | 5 | 1 | 15 |
| 9t | J. Simmons | Den | 16 | 93 | 0.0 | 0.0 | 4 | 0 | 15 |
| 11t | C. Awuzie | Dal | 16 | 79 | 0.0 | 0.0 | 1 | 0 | 14 |
| 11t | M. Humphrey | Bal | 16 | 65 | 0.0 | 0.0 | 3 | 2 | 14 |
| 11t | M. Lattimore | NO | 14 | 57 | 0.0 | 0.0 | 1 | 0 | 14 |
| 11t | M. Peters | Bal | 16 | 53 | 0.0 | 0.0 | 5 | 0 | 14 |
| 15t | J. Coleman | Det | 16 | 53 | 0.0 | 0.0 | 1 | 3 | 13 |
| 15t | G. Conley | Hou | 14 | 50 | 0.0 | 0.0 | 1 | 0 | 13 |
| 15t | S. Griffin | Sea | 14 | 65 | 0.0 | 0.0 | 0 | 0 | 13 |
| 15t | T. Herndon | Jax | 16 | 54 | 0.0 | 0.0 | 3 | 0 | 13 |
| 15t | J. Joseph | Hou | 14 | 51 | 0.0 | 0.0 | 1 | 0 | 13 |
| 15t | D. Slay | Det | 14 | 46 | 0.0 | 0.0 | 2 | 0 | 13 |
| 15t | M. Williams | NO | 15 | 53 | 0.0 | 0.0 | 4 | 1 | 13 |
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