NFL Leaders |
Passes Defensed
| Rank | Name | Team | G | TK | Sacks | Sack-Yds | Int | Fum | PD |
| 1 | X. Howard | Mia | 16 | 51 | 0.0 | 0.0 | 10 | 1 | 20 |
| 2t | J. Bradberry | NYG | 15 | 53 | 0.0 | 0.0 | 3 | 2 | 18 |
| 2t | C. Davis III | TB | 14 | 68 | 0.0 | 0.0 | 4 | 0 | 18 |
| 2t | D. Ward | Cle | 12 | 46 | 0.0 | 0.0 | 2 | 1 | 18 |
| 5 | R. Darby | Was | 16 | 55 | 0.0 | 0.0 | 0 | 0 | 16 |
| 6t | J. Bates III | Cin | 16 | 107 | 0.0 | 0.0 | 3 | 1 | 15 |
| 6t | J. Johnson | Chi | 13 | 44 | 0.0 | 0.0 | 0 | 0 | 15 |
| 8t | M. Butler | Ten | 16 | 100 | 0.0 | 0.0 | 4 | 0 | 14 |
| 8t | M. Davis | LAC | 16 | 63 | 0.0 | 0.0 | 3 | 0 | 14 |
| 8t | T. Diggs | Dal | 12 | 58 | 1.0 | 0.0 | 3 | 1 | 14 |
| 8t | J. Jackson | NE | 16 | 40 | 0.0 | 0.0 | 9 | 0 | 14 |
| 8t | T. Mullen | LV | 16 | 61 | 0.0 | 0.0 | 2 | 0 | 14 |
| 8t | D. Williams | LAR | 16 | 44 | 0.0 | 0.0 | 4 | 0 | 14 |
| 14t | J. Alexander | GB | 15 | 51 | 1.0 | 4.0 | 1 | 1 | 13 |
| 14t | C. Gardner-Johnson | NO | 15 | 65 | 1.0 | 6.0 | 1 | 0 | 13 |
| 14t | T. Mitchell | Cle | 16 | 65 | 0.0 | 0.0 | 0 | 3 | 13 |
| 14t | K. Moore II | Ind | 16 | 79 | 2.0 | 11.0 | 4 | 1 | 13 |
| 18t | S. Griffin | Sea | 12 | 63 | 0.0 | 0.0 | 3 | 0 | 12 |
| 18t | J. Haden | Pit | 14 | 52 | 0.0 | 0.0 | 2 | 0 | 12 |
| 18t | J. Jenkins | NO | 13 | 55 | 0.0 | 0.0 | 3 | 0 | 12 |
| 18t | D. Phillips | Cin | 12 | 36 | 0.0 | 0.0 | 1 | 2 | 12 |
| 18t | X. Rhodes | Ind | 16 | 42 | 0.0 | 0.0 | 2 | 0 | 12 |
| 18t | D. Savage | GB | 15 | 75 | 1.0 | 10.0 | 4 | 0 | 12 |
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