NFL Leaders |
Sacks
| Rank | Name | Team | G | TK | Sacks | Sack-Yds | Int | Fum | PD |
| 1 | N. Bosa | SF | 16 | 51 | 18.5 | 137.5 | 0 | 2 | 1 |
| 2t | M. Garrett | Cle | 16 | 60 | 16.0 | 91.0 | 0 | 2 | 4 |
| 2t | H. Reddick | Phi | 17 | 49 | 16.0 | 132.5 | 0 | 5 | 3 |
| 4t | C. Jones | KC | 17 | 44 | 15.5 | 105.5 | 0 | 2 | 4 |
| 4t | M. Judon | NE | 17 | 60 | 15.5 | 102.5 | 0 | 2 | 3 |
| 6 | A. Highsmith | Pit | 17 | 63 | 14.5 | 118.0 | 0 | 5 | 1 |
| 7 | M. Parsons | Dal | 17 | 65 | 13.5 | 88.5 | 0 | 3 | 3 |
| 8t | B. Burns | Car | 16 | 63 | 12.5 | 83.0 | 0 | 1 | 3 |
| 8t | M. Crosby | LV | 17 | 88 | 12.5 | 102.0 | 0 | 3 | 4 |
| 8t | J. Watt | Ari | 16 | 39 | 12.5 | 94.0 | 0 | 1 | 7 |
| 11 | Q. Williams | NYJ | 16 | 55 | 12.0 | 98.5 | 0 | 2 | 4 |
| 12t | D. Payne | Was | 17 | 64 | 11.5 | 81.5 | 0 | 0 | 5 |
| 12t | J. Uche | NE | 15 | 27 | 11.5 | 49.5 | 0 | 2 | 0 |
| 14t | B. Graham | Phi | 17 | 35 | 11.0 | 64.0 | 0 | 2 | 1 |
| 14t | J. Hargrave | Phi | 17 | 60 | 11.0 | 75.0 | 0 | 1 | 2 |
| 14t | J. Sweat | Phi | 16 | 48 | 11.0 | 84.0 | 1 | 1 | 1 |
| 17t | C. Heyward | Pit | 17 | 74 | 10.5 | 72.5 | 0 | 1 | 4 |
| 17t | D. Hunter | Min | 17 | 65 | 10.5 | 63.0 | 0 | 1 | 3 |
| 19 | Z. Smith | Min | 16 | 44 | 10.0 | 70.5 | 0 | 2 | 5 |
| 20t | J. Houston | Bal | 14 | 21 | 9.5 | 63.0 | 1 | 1 | 1 |
| 20t | A. Hutchinson | Det | 17 | 52 | 9.5 | 59.5 | 3 | 0 | 3 |
| 20t | Y. Ngakoue | Ind | 15 | 29 | 9.5 | 62.5 | 0 | 1 | 0 |
| 20t | U. Nwosu | Sea | 17 | 67 | 9.5 | 62.5 | 0 | 3 | 4 |
| 20t | D. Taylor | Sea | 16 | 26 | 9.5 | 73.5 | 0 | 4 | 1 |
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