NFL Leaders |
Rushing Yards Gained
| Rank | Name | Team | G | Rushes | Rush Yds | Yd/G | Avg | TD |
| 1 | D. Cook | Min | 13 | 249 | 1159 | 89.2 | 4.65 | 6 |
| 2 | A. Gibson | Was | 16 | 258 | 1037 | 64.8 | 4.02 | 7 |
| 3 | E. Elliott | Dal | 17 | 237 | 1002 | 58.9 | 4.23 | 10 |
| 4 | E. Mitchell | SF | 11 | 207 | 963 | 87.5 | 4.65 | 5 |
| 5 | A. Kamara | NO | 13 | 240 | 898 | 69.1 | 3.74 | 4 |
| 6 | D. Montgomery | Chi | 13 | 225 | 849 | 65.3 | 3.77 | 7 |
| 7 | S. Michel | LAR | 17 | 208 | 845 | 49.7 | 4.06 | 4 |
| 8 | L. Fournette | TB | 14 | 180 | 812 | 58.0 | 4.51 | 8 |
| 9 | A. Dillon | GB | 17 | 187 | 803 | 47.2 | 4.29 | 5 |
| 10 | A. Jones | GB | 15 | 171 | 799 | 53.3 | 4.67 | 4 |
| 11 | J. Hurts | Phi | 15 | 139 | 784 | 52.3 | 5.64 | 10 |
| 12 | M. Sanders | Phi | 12 | 137 | 754 | 62.8 | 5.50 | 0 |
| 13 | J. Conner | Ari | 15 | 202 | 752 | 50.1 | 3.72 | 15 |
| 14 | R. Penny | Sea | 10 | 119 | 749 | 74.9 | 6.29 | 6 |
| 15 | T. Pollard | Dal | 15 | 130 | 719 | 47.9 | 5.53 | 2 |
| 16 | D. Henderson Jr. | LAR | 12 | 149 | 688 | 57.3 | 4.62 | 5 |
| 17 | C. Patterson | Atl | 16 | 153 | 618 | 38.6 | 4.04 | 6 |
| 18 | D. Swift | Det | 13 | 151 | 617 | 47.5 | 4.09 | 5 |
| 19 | C. Hubbard | Car | 17 | 172 | 612 | 36.0 | 3.56 | 5 |
| 20 | J. Williams | Det | 13 | 153 | 601 | 46.2 | 3.93 | 3 |
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