NFL Leaders |
Rushing Touchdowns
| Rank | Name | Team | G | Rushes | Rush Yds | Yd/G | Avg | TD |
| 1 | J. Taylor | Ind | 17 | 332 | 1811 | 106.5 | 5.45 | 18 |
| 2 | D. Harris | NE | 15 | 202 | 929 | 61.9 | 4.60 | 15 |
| 3 | J. Mixon | Cin | 16 | 292 | 1205 | 75.3 | 4.13 | 13 |
| 4 | A. Ekeler | LAC | 16 | 206 | 911 | 56.9 | 4.42 | 12 |
| 5 | D. Henry | Ten | 8 | 219 | 937 | 117.1 | 4.28 | 10 |
| 6 | J. Jacobs | LV | 15 | 217 | 872 | 58.1 | 4.02 | 9 |
| 7t | N. Chubb | Cle | 14 | 228 | 1259 | 89.9 | 5.52 | 8 |
| 7t | M. Gordon III | Den | 16 | 203 | 918 | 57.4 | 4.52 | 8 |
| 7t | J. Robinson | Jax | 14 | 164 | 767 | 54.8 | 4.68 | 8 |
| 10t | N. Harris | Pit | 17 | 307 | 1200 | 70.6 | 3.91 | 7 |
| 10t | D. Singletary | Buf | 17 | 188 | 870 | 51.2 | 4.63 | 7 |
| 10t | R. Tannehill | Ten | 17 | 55 | 270 | 15.9 | 4.91 | 7 |
| 13t | J. Allen | Buf | 17 | 122 | 763 | 44.9 | 6.25 | 6 |
| 13t | L. Murray | Bal | 14 | 119 | 501 | 35.8 | 4.21 | 6 |
| 13t | D. Williams | KC | 17 | 144 | 558 | 32.8 | 3.88 | 6 |
| 16t | D. Freeman | Bal | 16 | 133 | 576 | 36.0 | 4.33 | 5 |
| 16t | K. Hunt | Cle | 8 | 78 | 386 | 48.3 | 4.95 | 5 |
| 16t | R. Stevenson | NE | 12 | 133 | 606 | 50.5 | 4.56 | 5 |
| 19t | M. Carter | NYJ | 14 | 147 | 639 | 45.6 | 4.35 | 4 |
| 19t | C. Edwards-Helaire | KC | 10 | 119 | 517 | 51.7 | 4.34 | 4 |
| 19t | Z. Moss | Buf | 13 | 96 | 345 | 26.5 | 3.59 | 4 |
| 19t | J. Williams | Den | 17 | 203 | 903 | 53.1 | 4.45 | 4 |
| 19t | Z. Wilson | NYJ | 13 | 29 | 185 | 14.2 | 6.38 | 4 |
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