| Saturday, 1 January 2022 |
| Time/Result | Home | Away | Venue |
| Postponed |
Leicester City |
Norwich City | King Power Stadium |
| 1-2 |
Arsenal |
Manchester City | Emirates Stadium |
| 0-1 |
Watford |
Tottenham Hotspur | Vicarage Road |
| 2-3 |
Crystal Palace |
West Ham United | Selhurst Park |
| Sunday, 2 January 2022 |
| Time/Result | Home | Away | Venue |
| Postponed |
Southampton |
Newcastle United | St. Mary's Stadium |
| 2-3 |
Everton |
Brighton & Hove Albion | Goodison Park |
| 3-1 |
Leeds United |
Burnley | Elland Road |
| 2-1 |
Brentford |
Aston Villa | Brentford Community Stadium |
| 2-2 |
Chelsea |
Liverpool | Stamford Bridge |
| Monday, 3 January 2022 |
| Time/Result | Home | Away | Venue |
| 0-1 |
Manchester United |
Wolves | Old Trafford |
| Tuesday, 11 January 2022 |
| Time/Result | Home | Away | Venue |
| Postponed |
Everton |
Leicester City | Goodison Park |
| 4-1 |
Southampton |
Brentford | St. Mary's Stadium |
| Wednesday, 12 January 2022 |
| Time/Result | Home | Away | Venue |
| 2-0 |
West Ham United |
Norwich City | London Stadium |
| Friday, 14 January 2022 |
| Time/Result | Home | Away | Venue |
| 1-1 |
Brighton & Hove Albion |
Crystal Palace | The American Express Community Stadium |
| Saturday, 15 January 2022 |
| Time/Result | Home | Away | Venue |
| Postponed |
Burnley |
Leicester City | Turf Moor |
| 1-0 |
Manchester City |
Chelsea | Etihad Stadium |
| 1-1 |
Newcastle United |
Watford | St. James' Park |
| 2-1 |
Norwich City |
Everton | Carrow Road |
| 3-1 |
Wolves |
Southampton | Molineux Stadium |
| 2-2 |
Aston Villa |
Manchester United | Villa Park |
| Sunday, 16 January 2022 |
| Time/Result | Home | Away | Venue |
| Postponed |
Tottenham Hotspur |
Arsenal | Tottenham Hotspur Stadium |
| 3-0 |
Liverpool |
Brentford | Anfield |
| 2-3 |
West Ham United |
Leeds United | London Stadium |
| Tuesday, 18 January 2022 |
| Time/Result | Home | Away | Venue |
| Postponed |
Burnley |
Watford | Turf Moor |
| 1-1 |
Brighton & Hove Albion |
Chelsea | The American Express Community Stadium |
| Wednesday, 19 January 2022 |
| Time/Result | Home | Away | Venue |
| 2-3 |
Leicester City |
Tottenham Hotspur | King Power Stadium |
| 1-3 |
Brentford |
Manchester United | Brentford Community Stadium |
| Friday, 21 January 2022 |
| Time/Result | Home | Away | Venue |
| 0-3 |
Watford |
Norwich City | Vicarage Road |
| Saturday, 22 January 2022 |
| Time/Result | Home | Away | Venue |
| 0-1 |
Everton |
Aston Villa | Goodison Park |
| 0-1 |
Leeds United |
Newcastle United | Elland Road |
| 1-0 |
Manchester United |
West Ham United | Old Trafford |
| 1-2 |
Brentford |
Wolves | Brentford Community Stadium |
| 1-1 |
Southampton |
Manchester City | St. Mary's Stadium |
| Sunday, 23 January 2022 |
| Time/Result | Home | Away | Venue |
| 0-0 |
Arsenal |
Burnley | Emirates Stadium |
| 1-1 |
Leicester City |
Brighton & Hove Albion | King Power Stadium |
| 1-3 |
Crystal Palace |
Liverpool | Selhurst Park |
| 2-0 |
Chelsea |
Tottenham Hotspur | Stamford Bridge |
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