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| Guangzhou International Women's Open | ||
| Surface: Hard | Date: Sep. 16 - Sep. 21 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Dalila Jakupovic | Win | 6-3, 6-3 |
| Second Round | Marie Bouzkova |
| Zhengzhou Open | ||
| Surface: Hard | Date: Sep. 9 - Sep. 15 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Win | 3-6, 6-1, 7-6 (7-5) |
| Quarterfinals | Kristina Mladenovic | Loss | 4-6, 6-4, 3-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Whitney Osuigwe | Win | 6-1, 7-5 |
| Second Round | Venus Williams | Win | 6-4, 6-4 |
| Third Round | Dayana Yastremska | Win | 6-2, 6-0 |
| Fourth Round | Madison Keys | Win | 7-5, 6-4 |
| Quarterfinals | Johanna Konta | Win | 6-4, 6-4 |
| Semifinals | Serena Williams | Loss | 3-6, 1-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elise Mertens | Win | 6-4, 6-1 |
| Third Round | Sofia Kenin | Loss | 3-6, 6-7 (3-7) |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Katerina Siniakova | Win | 6-3, 3-6, 6-3 |
| Third Round | Belinda Bencic | Win | 6-2, 6-4 |
| Quarterfinals | Sofia Kenin | Loss | 6-7 (2-7), 4-6 |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Jul. 29 - Aug. 4 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Kasatkina | Win | 6-3, 6-1 |
| Quarterfinals | Maria Sakkari | Loss | 6-1, 6-7 (3-7), 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Daria Gavrilova | Win | 7-5, 6-0 |
| Second Round | Margarita Gasparyan | Win | 5-7, 6-5 Retired |
| Third Round | Maria Sakkari | Win | 6-3, 6-7 (1-7), 6-2 |
| Fourth Round | Petra Martic | Win | 6-4, 6-2 |
| Quarterfinals | Karolina Muchova | Win | 7-5, 6-4 |
| Semifinals | Simona Halep | Loss | 1-6, 3-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alize Cornet | Loss | 3-6, 6-7 (3-7) |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Margarita Gasparyan | Loss | 3-6, 6-3, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Venus Williams | Win | 6-3, 6-3 |
| Second Round | Kateryna Kozlova | Win | Retired |
| Third Round | Garbine Muguruza | Loss | 3-6, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Victoria Azarenka | Loss | 6-4, 1-6, 5-7 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Pauline Parmentier | Loss | 4-6, 6-7 (6-8) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yafan Wang | Loss | 2-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sofia Kenin | Win | 3-6, 7-6 (7-5), 6-4 |
| Third Round | Daria Gavrilova | Win | 7-5, 6-4 |
| Fourth Round | Ashleigh Barty | Win | 7-6 (10-8), 5-7, 6-4 |
| Quarterfinals | Marketa Vondrousova | Win | 4-6, 6-4, 6-4 |
| Semifinals | Bianca Andreescu | Loss | 3-6, 6-2, 4-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ons Jabeur | Win | 7-6 (7-4), 4-0 Retired |
| Third Round | Garbine Muguruza | Win | 6-1, 6-2 |
| Quarterfinals | Carla Suarez Navarro | Win | 6-2, 6-3 |
| Semifinals | Belinda Bencic | Loss | 2-6, 6-3, 6-7 (3-7) |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 11 - Feb. 16 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jelena Ostapenko | Win | 6-4, 6-4 |
| Quarterfinals | Karolina Muchova | Win | 6-4, 6-2 |
| Semifinals | Simona Halep | Loss | 3-6, 6-3, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Viktorija Golubic | Win | 6-1, 6-2 |
| Second Round | Viktoria Kuzmova | Win | 6-4, 6-1 |
| Third Round | Shuai Zhang | Win | 4-6, 6-4, 7-5 |
| Fourth Round | Madison Keys | Win | 6-2, 1-6, 6-1 |
| Quarterfinals | Naomi Osaka | Loss | 4-6, 1-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aliaksandra Sasnovich | Loss | 4-6, 6-0, 3-6 |
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