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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Katerina Siniakova | Win | 6-0, 6-7 (5-7), 6-3 |
| Second Round | Evgeniya Rodina | Win | 6-4, 6-4 |
| Third Round | Shelby Rogers | Win | 6-4, 7-5 |
| Fourth Round | Madison Keys | Loss | 6-7 (2-7), 6-1, 4-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lesia Tsurenko | Win | 6-1, 6-4 |
| Third Round | Julia Goerges | Loss | 5-7, 4-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Kasatkina | Win | 7-6 (7-4), 6-4 |
| Third Round | Venus Williams | Win | 6-2, 6-1 |
| Quarterfinals | Garbine Muguruza | Win | 4-6, 6-4, 6-3 |
| Semifinals | Simona Halep | Win | 6-1, 6-1 |
| Final | Caroline Wozniacki | Win | 6-4, 6-0 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Ashleigh Barty | Win | 7-5, 7-6 (10-8) |
| Second Round | Francesca Schiavone | Win | 6-3, 6-0 |
| Third Round | Carina Witthoeft | Win | 6-1, 7-5 |
| Fourth Round | Jelena Ostapenko | Loss | 3-6, 6-7 (6-8) |
| AEGON Classic Birmingham | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Heather Watson | Win | 6-2, 5-7, 6-3 |
| Second Round | Camila Giorgi | Loss | 4-6, 6-4, 2-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Yaroslava Shvedova | Win | 6-4, 6-3 |
| Second Round | Tsvetana Pironkova | Win | 3-6, 6-3, 6-2 |
| Third Round | Magda Linette | Win | 6-4, 7-5 |
| Fourth Round | Petra Martic | Win | 4-6, 6-3, 7-5 |
| Quarterfinals | Simona Halep | Loss | 6-3, 6-7 (6-8), 0-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alize Cornet | Win | 6-4, 7-6 (13-11) |
| Third Round | Mona Barthel | Win | 3-6, 6-0, 6-0 |
| Quarterfinals | Karolina Pliskova | Win | 6-2, 7-6 (11-9) |
| Semifinals | Garbine Muguruza | Win | 4-1 Retired |
| Final | Simona Halep | Win | 4-6, 7-5, 6-1 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Loss | 6-2, 6-7 (4-7), 3-6 |
| TEB BNP Paribas Istanbul Cup | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Victoria Kamenskaya | Win | 6-4, 0-6, 6-1 |
| Second Round | Alexandra Cadantu | Win | 6-3, 6-3 |
| Quarterfinals | Sorana Cirstea | Win | 6-4, 6-4 |
| Semifinals | Jana Cepelova | Win | 6-2, 6-3 |
| Final | Elise Mertens | Win | 6-2, 6-4 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Bethanie Mattek-Sands | Loss | 5-7, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Qiang Wang | Win | 3-6, 6-3, 7-6 (7-3) |
| Third Round | Daria Gavrilova | Win | 6-2, 6-1 |
| Fourth Round | Garbine Muguruza | Loss | 6-7 (5-7), 6-1, 0-6 |
| Alya WTA Malaysian Open | ||
| Surface: Hard | Date: Feb. 27 - Mar. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Su Jeong Jang | Win | 6-2, 6-3 |
| Second Round | Nao Hibino | Loss | Retired |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Saisai Zheng | Win | 7-5, 6-1 |
| Third Round | Christina McHale | Win | 4-6, 6-4, 6-3 |
| Quarterfinals | Lauren Davis | Win | 6-0, 6-4 |
| Semifinals | Angelique Kerber | Win | 6-3, 7-6 (7-3) |
| Final | Caroline Wozniacki | Win | 6-4, 6-2 |
| Taiwan Open | ||
| Surface: Hard | Date: Jan. 30 - Feb. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Evgeniya Rodina | Win | 6-0, 6-3 |
| Second Round | Lucie Hradecka | Win | 6-4, 7-5 |
| Quarterfinals | Ons Jabeur | Win | 6-1, 3-6, 7-6 (7-4) |
| Semifinals | Mandy Minella | Win | 6-3, 6-2 |
| Final | Shuai Peng | Win | 6-3, 6-2 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Galina Voskoboeva | Win | 6-0, 6-2 |
| Second Round | Julia Boserup | Win | 6-4, 6-1 |
| Third Round | Anastasia Pavlyuchenkova | Loss | 5-7, 6-4, 3-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Monica Puig | Win | 6-3, 6-3 |
| Second Round | Shelby Rogers | Win | 7-5, 2-6, 7-5 |
| Quarterfinals | Angelique Kerber | Win | 6-4, 3-6, 6-3 |
| Semifinals | Karolina Pliskova | Loss | 2-6, 4-6 |
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