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| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Rebecca Marino | Win | 6-2, 6-3 |
| Second Round | Rebeka Masarova | Win | 6-2, 7-5 |
| Third Round | Daria Kasatkina | Win | 6-4, 6-2 |
| Fourth Round | Simona Halep | Win | 6-3, 6-3 |
| Quarterfinals | Leylah Fernandez | Loss | 3-6, 6-3, 6-7 (5-7) |
| Chicago Women's Open | ||
| Surface: Hard | Date: Aug. 22 - Aug. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Clara Burel | Win | 5-7, 6-1, 2-0 Retired |
| Second Round | Fiona Ferro | Win | 6-4, 6-4 |
| Quarterfinals | Kristina Mladenovic | Win | 6-1, 6-0 |
| Semifinals | Rebecca Peterson | Win | 6-1, 6-7 (4-7), 6-3 |
| Final | Alize Cornet | Win | 7-5, 6-4 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Angelique Kerber | Loss | 5-7, 6-2, 4-6 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Johanna Konta | Loss | 6-3, 3-6, 2-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Alison Van Uytvanck | Win | 6-3, 2-6, 6-3 |
| Second Round | Magda Linette | Loss | 3-6, 4-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 21 - Jun. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Paula Badosa | Win | 4-6, 6-1, 7-6 (7-1) |
| Second Round | Elena Rybakina | Loss | 4-6, 6-7 (3-7) |
| bett1open | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ekaterina Alexandrova | Loss | 4-6, 5-7 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Oceane Babel | Win | 6-2, 7-5 |
| Second Round | Ann Li | Win | 6-0, 6-4 |
| Third Round | Barbora Krejcikova | Loss | 3-6, 2-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Amanda Anisimova | Win | 2-6, 6-3, 6-4 |
| Third Round | Garbine Muguruza | Win | 6-4, 6-2 |
| Quarterfinals | Iga Swiatek | Loss | 2-6, 5-7 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Jil Teichmann | Loss | 6-2, 4-6, 6-7 (5-7) |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Angelique Kerber | Win | 7-6 (7-4), 6-3 |
| Quarterfinals | Petra Kvitova | Win | 6-7 (4-7), 7-5, 6-2 |
| Semifinals | Ashleigh Barty | Loss | 6-4, 6-7 (5-7), 2-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Shelby Rogers | Win | 3-6, 7-5, 6-3 |
| Third Round | Ekaterina Alexandrova | Win | 7-6 (7-1), 6-4 |
| Fourth Round | Petra Kvitova | Win | 2-6, 7-5, 7-5 |
| Quarterfinals | Anastasija Sevastova | Win | 6-3, 6-2 |
| Semifinals | Ashleigh Barty | Loss | 3-6, 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Svetlana Kuznetsova | Loss | 6-2, 4-6, 1-6 |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Misaki Doi | Win | 6-1, 6-2 |
| Quarterfinals | Victoria Azarenka | Loss | 2-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Marie Bouzkova | Win | 6-3, 7-6 (7-5) |
| Second Round | Cori Gauff | Win | 6-4, 6-3 |
| Third Round | Yulia Putintseva | Win | 6-4, 6-0 |
| Fourth Round | Jessica Pegula | Loss | 4-6, 6-3, 3-6 |
| Gippsland Trophy | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andrea Petkovic | Win | 6-1, 6-4 |
| Third Round | Jelena Ostapenko | Win | 6-7 (4-7), 6-3, 6-2 |
| Quarterfinals | Elise Mertens | Loss | 3-6, 7-5, 6-10 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Jessica Pegula | Win | 6-4, 6-3 |
| Second Round | Vera Zvonareva | Win | 6-4, 6-1 |
| Third Round | Ekaterina Alexandrova | Win | 6-2, 6-7 (5-7), 7-6 (10-8) |
| Quarterfinals | Veronika Kudermetova | Loss | 7-5, 3-6, 6-7 (3-7) |
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