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| BGL BNP Paribas Luxembourg Open | ||
| Surface: Hard | Date: Oct. 14 - Oct. 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Misaki Doi | Win | 5-7, 6-1, 6-3 |
| Second Round | Sorana Cirstea | Win | 4-6, 6-4, 6-4 |
| Quarterfinals | Monica Puig | Win | 1-6, 6-2, 6-3 |
| Semifinals | Elena Rybakina | Win | 6-3, 6-4 |
| Final | Jelena Ostapenko | Loss | 4-6, 1-6 |
| Upper Austria Ladies Linz | ||
| Surface: Hard | Date: Oct. 7 - Oct. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Margarita Gasparyan | Win | 6-4, 6-2 |
| Second Round | Andrea Petkovic | Loss | 6-7 (2-7), 0-6 |
| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Loss | 7-6 (7-4), 6-7 (5-7), 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 26 |
| Round | Opponent | W / L | Result |
| First Round | Natalia Vikhlyantseva | Win | 1-6, 6-1, 7-6 (7-1) |
| Second Round | Francesca Di Lorenzo | Win | 7-5, 6-0 |
| Third Round | Kiki Bertens | Win | 6-2, 6-3 |
| Fourth Round | Donna Vekic | Loss | 7-6 (7-5), 5-7, 3-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Sofia Kenin | Loss | 4-6, 6-7 (6-8) |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Win | 6-3, 1-6, 7-6 (7-5) |
| Second Round | Belinda Bencic | Loss | 7-5, 3-6, 4-6 |
| Ladies Championship Lausanne | ||
| Surface: Clay | Date: Jul. 15 - Jul. 21 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Simona Waltert | Loss | 7-6 (7-5), 4-6, 2-3 Retired |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Elena-Gabriela Ruse | Win | 7-5, 6-1 |
| Second Round | Varvara Flink | Win | 6-1, 6-4 |
| Third Round | Serena Williams | Loss | 3-6, 4-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Dayana Yastremska | Win | 3-6, 6-4, 6-3 |
| Second Round | Evgeniya Rodina | Win | 6-4, 6-3 |
| Quarterfinals | Yulia Putintseva | Win | 6-3, 6-2 |
| Semifinals | Petra Martic | Win | 6-4, 6-3 |
| Final | Ashleigh Barty | Loss | 3-6, 5-7 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Kaia Kanepi | Loss | 5-7, 1-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Su-Wei Hsieh | Win | 6-3, 6-4 |
| Second Round | Mihaela Buzarnescu | Loss | 4-6, 6-3, 4-4 Retired |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Viktoria Kuzmova | Loss | 5-7, 4-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Pavlyuchenkova | Loss | 6-4, 2-6, 0-4 Retired |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 1 - Apr. 7 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Taylor Townsend | Loss | 4-6, 6-7 (0-7) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magdalena Rybarikova | Win | 6-4, 7-5 |
| Third Round | Caroline Garcia | Loss | 0-6, 5-7 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kaia Kanepi | Win | 6-3, 2-6, 6-3 |
| Third Round | Mona Barthel | Loss | 5-7, 6-1, 4-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Loss | 4-6, 5-7 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 11 - Feb. 16 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Ajla Tomljanovic | Win | 6-2, 6-2 |
| Second Round | Alison Riske | Win | 6-1, 6-7 (5-7), 6-4 |
| Quarterfinals | Simona Halep | Loss | 6-7 (1-7), 6-7 (6-8) |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Jan. 28 - Feb. 3 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Maria Sakkari | Win | 6-2, 7-5 |
| Second Round | Vera Zvonareva | Loss | 6-4, 4-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Danielle Collins | Loss | 6-2, 6-7 (5-7), 4-6 |
| ASB Classic | ||
| Surface: Hard | Date: Dec. 31 - Jan. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Johanna Larsson | Win | 6-0, 6-4 |
| Second Round | Mona Barthel | Win | 6-4, 6-4 |
| Quarterfinals | Eugenie Bouchard | Win | 3-6, 6-3, 7-6 (7-6) |
| Semifinals | Viktoria Kuzmova | Win | 6-1, 7-6 (7-6) |
| Final | Bianca Andreescu | Win | 2-6, 7-5, 6-1 |
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