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| BGL BNP Paribas Luxembourg Open | ||
| Surface: Hard | Date: Oct. 15 - Oct. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Viktoria Kuzmova | Win | 6-4, 6-3 |
| Second Round | Anna Blinkova | Win | 6-1, 6-4 |
| Quarterfinals | Donna Vekic | Win | 6-3, 3-6, 6-3 |
| Semifinals | Eugenie Bouchard | Win | 6-7 (3-7), 7-5, 6-1 |
| Final | Belinda Bencic | Win | 6-4, 7-5 |
| Upper Austria Ladies Linz | ||
| Surface: Hard | Date: Oct. 8 - Oct. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Andrea Petkovic | Loss | 6-1, 5-7, 4-6 |
| China Open | ||
| Surface: Hard | Date: Sep. 29 - Oct. 7 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Johanna Konta | Win | 6-2, 4-6, 6-3 |
| Second Round | Lesia Tsurenko | Win | 6-4, 4-6, 2-2 Retired |
| Third Round | Naomi Osaka | Loss | 1-6, 2-6 |
| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 23 - Sep. 29 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Marketa Vondrousova | Win | 6-3, 3-6, 7-6 (7-4) |
| Second Round | Sofia Kenin | Loss | 3-6, 6-2, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 27 - Sep. 9 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Anna Kalinskaya | Win | 6-2, 6-7 (5-7), 6-2 |
| Second Round | Ekaterina Makarova | Loss | 6-7 (10-12), 3-6 |
| Connecticut Open presented by United Technologies | ||
| Surface: Hard | Date: Aug. 19 - Aug. 25 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Dominika Cibulkova | Win | 6-3, 6-1 |
| Second Round | Dayana Yastremska | Win | 6-4, 3-6, 6-4 |
| Quarterfinals | Ekaterina Makarova | Win | 6-4, 6-2 |
| Semifinals | Aryna Sabalenka | Loss | 4-6, 6-7 (3-7) |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Kristina Mladenovic | Loss | 4-6, 2-3 Retired |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 6 - Aug. 12 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Timea Babos | Win | 3-6, 7-6 (7-3), 6-4 |
| Second Round | Lucie Safarova | Win | 2-6, 6-4, 6-3 |
| Third Round | Anastasija Sevastova | Loss | 3-6, 6-7 (2-7) |
| Moscow River Cup presented by O1 Properties | ||
| Surface: Hard | Date: Jul. 23 - Jul. 29 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Viktoria Kuzmova | Win | 6-1, 6-0 |
| Second Round | Natalia Vikhlyantseva | Win | 6-2, 7-6 (7-2) |
| Quarterfinals | Olga Danilovic | Loss | 3-6, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Monica Puig | Win | 6-4, 7-6 (9-7) |
| Second Round | Vera Lapko | Win | 6-2, 3-6, 6-2 |
| Third Round | Barbora Strycova | Win | 7-6 (7-3), 3-6, 10-8 |
| Fourth Round | Donna Vekic | Win | 6-3, 6-2 |
| Quarterfinals | Kiki Bertens | Win | 3-6, 7-5, 6-1 |
| Semifinals | Serena Williams | Loss | 2-6, 4-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 24 - Jun. 30 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aryna Sabalenka | Loss | 6-1, 4-6, 4-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Maria Sakkari | Win | 6-4, 6-4 |
| Second Round | Ashleigh Barty | Win | 7-6 (8-6), 6-3 |
| Quarterfinals | Petra Kvitova | Loss | 1-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Dominika Cibulkova | Win | 6-4, 5-7, 6-0 |
| Second Round | Alison Van Uytvanck | Win | 7-5, 7-6 (7-5) |
| Third Round | Serena Williams | Loss | 3-6, 4-6 |
| Nurnberger Versicherungscup | ||
| Surface: Clay | Date: May 20 - May 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Kristyna Pliskova | Loss | 2-6, 7-6 (10-8), 6-7 (5-7) |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Timea Babos | Win | 6-2, 6-4 |
| Second Round | Lara Arruabarrena | Win | 2-6, 6-4, 6-2 |
| Third Round | Caroline Garcia | Loss | 2-6, 4-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 23 - Apr. 29 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Marketa Vondrousova | Loss | 2-6, 2-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 2 - Apr. 8 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristie Ahn | Win | 2-6, 6-4, 7-6 (7-1) |
| Third Round | Naomi Osaka | Win | 7-6 (7-4), 6-3 |
| Quarterfinals | Daria Kasatkina | Win | 6-4, 6-3 |
| Semifinals | Anastasija Sevastova | Win | 7-6 (7-5), 6-3 |
| Final | Kiki Bertens | Loss | 2-6, 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Carina Witthoeft | Loss | 6-7 (2-7), 6-4, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Natalia Vikhlyantseva | Win | 6-4, 6-1 |
| Third Round | Anastasija Sevastova | Loss | 3-6, 3-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 12 - Feb. 18 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Lucie Safarova | Win | 6-1, 7-5 |
| Second Round | Barbora Strycova | Win | 6-2, 3-6, 6-1 |
| Third Round | Mihaela Buzarnescu | Win | 6-2, 6-2 |
| Quarterfinals | Petra Kvitova | Loss | 4-6, 1-2 Retired |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Jan. 29 - Feb. 4 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Maria Sakkari | Win | 6-2, 7-6 (7-5) |
| Second Round | Roberta Vinci | Win | 7-5, 6-0 |
| Quarterfinals | Elena Rybakina | Win | 6-3, 6-3 |
| Semifinals | Petra Kvitova | Loss | 5-7, 6-4, 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Sofia Kenin | Win | 6-4, 6-4 |
| Second Round | Alize Cornet | Loss | 4-6, 3-6 |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 1 - Jan. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Monica Puig | Win | 6-4, 4-6, 6-2 |
| Second Round | Viktoria Kuzmova | Win | 6-4, 6-0 |
| Quarterfinals | Polona Hercog | Win | 6-4, 6-4 |
| Semifinals | Su-Wei Hsieh | Win | 6-1, 6-4 |
| Final | Caroline Wozniacki | Win | 6-4, 7-6 (7-4) |
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