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| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 24 - Sep. 30 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Caroline Garcia | Loss | 6-3, 3-6, 1-6 |
| Toray Pan Pacific Open | ||
| Surface: Hard | Date: Sep. 18 - Sep. 24 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Naomi Osaka | Win | 6-3, 6-4 |
| Second Round | Daria Kasatkina | Win | 7-6 (7-5), 6-3 |
| Quarterfinals | Karolina Pliskova | Win | 7-6 (7-5), 7-5 |
| Semifinals | Anastasia Pavlyuchenkova | Loss | 0-6, 7-6 (7-4), 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Naomi Osaka | Loss | 3-6, 1-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ekaterina Makarova | Loss | 4-6, 6-1, 6-7 (11-13) |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Donna Vekic | Win | 6-4, 7-6 (7-5) |
| Third Round | Sloane Stephens | Loss | 2-6, 2-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Irina Falconi | Win | 6-4, 6-4 |
| Second Round | Kirsten Flipkens | Win | 7-5, 7-5 |
| Third Round | Shelby Rogers | Win | 4-6, 7-6 (7-2), 6-4 |
| Fourth Round | Garbine Muguruza | Loss | 6-4, 4-6, 4-6 |
| AEGON International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristyna Pliskova | Win | 4-6, 6-1, 7-5 |
| Third Round | Lara Arruabarrena | Win | 6-2, 6-1 |
| Quarterfinals | Johanna Konta | Loss | 3-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Ekaterina Makarova | Loss | 2-6, 2-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anett Kontaveit | Loss | 4-6, 0-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Timea Babos | Win | 6-4, 6-2 |
| Second Round | Katerina Siniakova | Win | 6-2, 1-6, 7-5 |
| Third Round | Eugenie Bouchard | Loss | 3-6, 0-5 Retired |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristina Mladenovic | Loss | 2-6, 5-7 |
| Open Monterrey GNP Seguros | ||
| Surface: Hard | Date: Apr. 3 - Apr. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Francesca Schiavone | Win | 4-6, 6-0, 6-4 |
| Second Round | Mandy Minella | Win | 6-1, 6-3 |
| Quarterfinals | Heather Watson | Win | 6-4, 6-4 |
| Semifinals | Carla Suarez Navarro | Win | 7-6 (8-6), 6-1 |
| Final | Anastasia Pavlyuchenkova | Loss | 4-6, 6-2, 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ying-Ying Duan | Win | 7-6 (7-3), 6-2 |
| Third Round | Shelby Rogers | Win | 6-4, 7-5 |
| Fourth Round | Risa Ozaki | Win | 6-2, 6-2 |
| Quarterfinals | Venus Williams | Loss | 5-7, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andrea Petkovic | Win | 6-2, 6-1 |
| Third Round | Pauline Parmentier | Win | 7-5, 3-6, 7-5 |
| Fourth Round | Elena Vesnina | Loss | 3-6, 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mona Barthel | Win | 6-4, 6-3 |
| Third Round | Monica Puig | Win | 6-2, 6-3 |
| Quarterfinals | Ana Konjuh | Win | 6-3, 6-2 |
| Semifinals | Elina Svitolina | Loss | 3-6, 6-7 (3-7) |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Kasatkina | Loss | 4-6, 6-0, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Lesia Tsurenko | Win | 6-2, 5-7, 6-2 |
| Second Round | Carina Witthoeft | Win | 6-2, 6-7 (3-7), 6-2 |
| Third Round | Kristyna Pliskova | Win | 6-0, 6-4 |
| Fourth Round | Coco Vandeweghe | Loss | 2-6, 3-6 |
| Apia International Sydney | ||
| Surface: Hard | Date: Jan. 8 - Jan. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Kasatkina | Loss | 6-7 (5-7), 2-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ashleigh Barty | Win | 6-3, 2-6, 6-3 |
| Quarterfinals | Elina Svitolina | Loss | 4-6, 6-3, 3-6 |
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