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| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 6 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Shuai Zhang | Win | 6-2, 1-6, 6-4 |
| Second Round | Polona Hercog | Loss | 4-6, 2-6 |
| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 22 - Sep. 28 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Monica Puig | Loss | 6-7 (5-7), 7-5, 1-6 |
| Toray Pan Pacific Open | ||
| Surface: Decoturf | Date: Sep. 16 - Sep. 22 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nicole Gibbs | Win | 6-2, 6-4 |
| Quarterfinals | Madison Keys | Win | 6-4, 4-6, 2-1 Retired |
| Semifinals | Anastasia Pavlyuchenkova | Loss | 3-6, 3-6 |
| Zhengzhou Open | ||
| Surface: Hard | Date: Sep. 9 - Sep. 15 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Loss | 7-5, 4-6, 6-7 (6-8) |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Kristina Mladenovic | Loss | 5-7, 6-0, 4-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Anett Kontaveit | Loss | 6-7 (7-9), 2-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Daria Kasatkina | Loss | 6-0, 2-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Tatjana Maria | Win | 6-4, 6-3 |
| Second Round | Lauren Davis | Loss | 6-2, 2-6, 1-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Samantha Stosur | Win | 6-4, 6-4 |
| Third Round | Rebecca Peterson | Win | 7-6 (7-4), 6-0 |
| Quarterfinals | Simona Halep | Win | 6-4, 6-3 |
| Semifinals | Ons Jabeur | Win | Retired |
| Final | Karolina Pliskova | Loss | 1-6, 4-6 |
| Mallorca Open | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Ysaline Bonaventure | Win | 7-5, 4-6, 6-2 |
| Second Round | Maria Sharapova | Win | 6-2, 6-3 |
| Quarterfinals | Caroline Garcia | Win | 6-3, 7-6 (7-5) |
| Semifinals | Belinda Bencic | Loss | 6-2, 6-7 (2-7), 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Potapova | Loss | 4-6, 2-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Lesia Tsurenko | Win | 6-3, 6-2 |
| Second Round | Petra Martic | Loss | Retired |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andrea Petkovic | Win | 6-2, 6-4 |
| Quarterfinals | Kiki Bertens | Loss | 3-6, 4-6 |
| Abierto GNP Seguros | ||
| Surface: Hard | Date: Apr. 1 - Apr. 7 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Kristina Kucova | Win | 7-6 (7-4), 6-2 |
| Second Round | Karolina Muchova | Win | 6-3, 6-4 |
| Quarterfinals | Kirsten Flipkens | Win | 6-2, 6-4 |
| Semifinals | Victoria Azarenka | Loss | 4-6, 6-4, 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Karolina Muchova | Win | 3-6, 6-3, 6-3 |
| Third Round | Bianca Andreescu | Loss | 4-6, 6-4, 1-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Win | 6-0, 6-2 |
| Third Round | Natalia Vikhlyantseva | Win | 3-6, 6-1, 6-3 |
| Fourth Round | Aryna Sabalenka | Win | 6-1, 4-6, 6-4 |
| Quarterfinals | Venus Williams | Win | 7-6 (7-3), 6-3 |
| Semifinals | Belinda Bencic | Win | 6-4, 6-2 |
| Final | Bianca Andreescu | Loss | 4-6, 6-3, 4-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dalila Jakupovic | Win | 7-6 (7-4), 6-3 |
| Third Round | Su-Wei Hsieh | Loss | 7-5, 4-6, 0-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 11 - Feb. 16 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anett Kontaveit | Win | 6-1, 7-6 (7-3) |
| Quarterfinals | Barbora Strycova | Win | 1-6, 6-2, 7-6 (7-4) |
| Semifinals | Elise Mertens | Loss | 4-6, 6-2, 1-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Win | 6-2, 6-2 |
| Second Round | Beatriz Haddad Maia | Win | 6-2, 6-3 |
| Third Round | Kimberly Birrell | Win | 6-1, 6-0 |
| Fourth Round | Danielle Collins | Loss | 0-6, 2-6 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 6 - Jan. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Camila Giorgi | Win | 7-6 (7-3), 6-2 |
| Quarterfinals | Petra Kvitova | Loss | 4-6, 1-6 |
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