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| St. Petersburg Open | ||
| Surface: Hard | Date: Sep. 18 - Sep. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Rogerio Dutra Silva | Win | 6-4, 4-6, 6-0 |
| Quarterfinals | Viktor Troicki |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Andreas Seppi | Win | 6-2, 4-6, 6-2, 7-6(7-1) |
| Second Round | Dustin Brown | Win | 6-1, 6-3, 7-6 (7-3) |
| Third Round | Juan Martin Del Potro | Loss | 3-6, 3-6, 4-6 |
| Winston-Salem Open | ||
| Surface: Hard | Date: Aug. 20 - Aug. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dusan Lajovic | Win | 6-4, 6-3 |
| Third Round | Marcos Baghdatis | Win | 6-3, 6-4 |
| Quarterfinals | Taylor Fritz | Win | 6-2, 7-6 (7-3) |
| Semifinals | Jan-Lennard Struff | Win | 6-2, 6-4 |
| Final | Damir Dzumhur | Win | 6-4, 6-4 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Jared Donaldson | Loss | 6-7 (5-7), 3-6 |
| Coupe Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Tim Smyczek | Win | 7-6 (7-4), 6-1 |
| Second Round | Ryan Harrison | Win | 7-5, 6-2 |
| Third Round | Gael Monfils | Win | 4-6, 7-6 (7-5), 7-6 (7-2) |
| Quarterfinals | Roger Federer | Loss | 4-6, 4-6 |
| J. Safra Sarasin Suisse Open Gstaad | ||
| Surface: Clay | Date: Jul. 24 - Jul. 30 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gleb Sakharov | Win | 6-4, 6-3 |
| Quarterfinals | Denis Istomin | Win | 6-3, 6-4 |
| Semifinals | Fabio Fognini | Loss | 7-5, 2-6, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Andreas Haider-Maurer | Win | 6-3, 6-1, 6-2 |
| Second Round | Peter Gojowczyk | Win | 6-2, 6-1, 3-6, 6-3 |
| Third Round | Kei Nishikori | Win | 6-4, 7-6 (7-3), 3-6, 6-3 |
| Fourth Round | Marin Cilic | Loss | 2-6, 2-6, 2-6 |
| Gerry Weber Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Carlos Berlocq | Win | 6-0, 4-6, 6-2 |
| Second Round | Dustin Brown | Win | 6-4, 1-6, 7-6 (8-6) |
| Quarterfinals | Alexander Zverev | Loss | 7-6 (8-6), 6-7 (1-7), 1-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | John Millman | Win | 6-2, 6-2, 0-6, 6-1 |
| Second Round | Mikhail Kukushkin | Win | 6-3, 3-6, 6-3, 7-6(7-3) |
| Third Round | Jiri Vesely | Win | 6-3, 6-4, 6-3 |
| Fourth Round | Rafael Nadal | Loss | 1-6, 2-6, 2-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alexandr Dolgopolov | Win | 6-4, 6-2 |
| Second Round | Pablo Carreno Busta | Win | 6-7 (6-8), 6-1, 6-4 |
| Third Round | Novak Djokovic | Loss | 4-6, 4-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ivo Karlovic | Loss | 6-7 (4-7), 7-6 (11-9), 6-7 (7-9) |
| BMW Open by FWU AG | ||
| Surface: Red Clay | Date: May 1 - May 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marius Copil | Win | 4-6, 7-6 (7-3), 7-5 |
| Quarterfinals | Yannick Hanfmann | Win | 6-3, 6-3 |
| Semifinals | Alexander Zverev | Loss | 5-7, 5-7 |
| Barcelona Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jan-Lennard Struff | Win | 6-1, 6-3 |
| Third Round | Albert Ramos-Vinolas | Loss | 2-6, 6-3, 4-6 |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 16 - Apr. 23 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Nikoloz Basilashvili | Win | 1-6, 6-3, 7-5 |
| Second Round | Diego Schwartzman | Loss | 3-6, 6-7 (3-7) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikhail Kukushkin | Win | 6-3, 7-6 (7-3) |
| Third Round | Sam Querrey | Win | 3-6, 6-2, 6-3 |
| Fourth Round | Roger Federer | Loss | 6-7 (5-7), 6-7 (4-7) |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Adrian Mannarino | Win | 7-5, 6-2 |
| Third Round | Pablo Carreno Busta | Loss | Retired |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Karen Khachanov | Win | 6-1, 7-6 (7-4) |
| Second Round | Fernando Verdasco | Loss | 4-6, 6-3, 5-7 |
| Garanti Koza Sofia Open | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Cedrik-Marcel Stebe | Win | 7-6 (7-4), 6-3 |
| Quarterfinals | Gilles Muller | Win | 7-5, 7-6 (7-5) |
| Semifinals | David Goffin | Loss | 7-5, 4-6, 6-7 (3-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Guido Pella | Win | 6-3, 6-1, 6-1 |
| Second Round | Yoshihito Nishioka | Win | 6-2, 6-3, 6-3 |
| Third Round | David Ferrer | Win | 7-5, 6-7 (6-8), 7-6 (7-3), 6-4 |
| Fourth Round | Milos Raonic | Loss | 6-7 (6-8), 6-3, 4-6, 1-6 |
| Aircel Chennai Open | ||
| Surface: Hard | Date: Jan. 2 - Jan. 8 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Rogerio Dutra Silva | Win | 6-3, 6-2 |
| Quarterfinals | Mikhail Youzhny | Win | 2-6, 6-4, 6-4 |
| Semifinals | Benoit Paire | Win | 6-3, 6-3 |
| Final | Daniil Medvedev | Win | 6-3, 6-4 |
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