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| Moselle Open | ||
| Surface: Hard | Date: Sep. 16 - Sep. 22 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Marius Copil | Win | 6-3, 6-4 |
| Second Round | Aljaz Bedene | Loss | 6-7 (9-11), 2-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Bjorn Fratangelo | Win | 5-7, 7-5, 7-5, 7-5 |
| Second Round | Andrey Rublev | Loss | 2-6 Retired |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Pablo Carreno Busta | Loss | 5-7, 6-7 (4-7) |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Radu Albot | Loss | 4-6, 2-6 |
| Citi Open | ||
| Surface: Hard | Date: Jul. 29 - Aug. 4 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nick Kyrgios | Loss | 4-6, 6-7 (5-7) |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Salvatore Caruso | Win | 7-6 (9-7), 6-3, 6-2 |
| Second Round | Tennys Sandgren | Loss | 2-6, 3-6, 6-4, 6-3, 6-8 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Tennys Sandgren | Win | 7-5, 6-1 |
| Second Round | Nicolas Jarry | Win | 6-2, 6-4 |
| Quarterfinals | Thomas Fabbiano | Loss | 4-6, 3-6 |
| Fever-Tree Championships | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | James Ward | Win | 3-6, 6-3, 7-6 (7-2) |
| Second Round | Kevin Anderson | Win | 6-1, 4-6, 6-4 |
| Quarterfinals | Nicolas Mahut | Win | 7-6 (7-5), 5-7, 7-6 (7-3) |
| Semifinals | Daniil Medvedev | Win | 6-7 (4-7), 6-4, 6-3 |
| Final | Feliciano Lopez | Loss | 2-6, 7-6 (7-4), 6-7 (2-7) |
| MercedesCup | ||
| Surface: Grass | Date: Jun. 10 - Jun. 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Peter Gojowczyk | Win | 4-6, 6-2, 6-3 |
| Second Round | Felix Auger-Aliassime | Loss | 5-7, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 26 |
| Round | Opponent | W / L | Result |
| First Round | Sergiy Stakhovsky | Win | 6-3, 6-3, 6-4 |
| Second Round | Salvatore Caruso | Loss | 1-6, 2-6, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Philipp Kohlschreiber | Loss | 2-6, 6-3, 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Hugo Dellien | Loss | 6-4, 1-6, 6-7 (4-7) |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Loss | 3-6, 2-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 14 - Apr. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alexei Popyrin | Win | 7-5, 6-1 |
| Second Round | Fabio Fognini | Loss | Retired |
| Grand Prix Hassan II | ||
| Surface: Red Clay | Date: Apr. 8 - Apr. 14 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Jozef Kovalik | Win | 6-4, 6-1 |
| Second Round | Guido Andreozzi | Win | 6-2, 6-2 |
| Quarterfinals | Taro Daniel | Win | 6-4, 7-5 |
| Semifinals | Pablo Andujar | Loss | 1-6, 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 23 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jeremy Chardy | Loss | 4-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 27 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Malek Jaziri | Win | 6-3, 6-7 (6-8), 6-4 |
| Third Round | Dominic Thiem | Loss | 3-6, 1-6 |
| Open 13 Provence | ||
| Surface: Hard | Date: Feb. 18 - Feb. 24 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Antoine Hoang | Win | 5-7, 6-3, 6-3 |
| Second Round | Peter Gojowczyk | Win | 4-6, 6-4, 6-2 |
| Quarterfinals | David Goffin | Loss | 2-6, 4-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 11 - Feb. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Tomas Berdych | Loss | 6-7 (8-10), 4-6 |
| Open Sud de France | ||
| Surface: Hard | Date: Feb. 4 - Feb. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jo-Wilfried Tsonga | Loss | 2-6, 6-7 (3-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 29 |
| Round | Opponent | W / L | Result |
| First Round | Bjorn Fratangelo | Win | 7-6 (7-2), 6-4, 6-2 |
| Second Round | Alex Bolt | Loss | 6-2, 4-6, 6-4, 6-7 (8-10), 4-6 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 6 - Jan. 12 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sam Querrey | Win | 7-6 (7-5), 6-7 (6-7), 6-4 |
| Quarterfinals | John Millman | Win | 7-5, 3-6, 7-6 (7-3) |
| Semifinals | Alex De Minaur | Loss | 3-6, 2-6 |
| Tata Open Maharashtra | ||
| Surface: Hard | Date: Dec. 31 - Jan. 5 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ilya Ivashka | Win | 6-7 (3-7), 6-2, 6-1 |
| Quarterfinals | Benoit Paire | Win | 3-6, 7-6 (7-4), 6-4 |
| Semifinals | Kevin Anderson | Loss | 3-6, 6-7 (3-7) |
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