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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 31 |
| Round | Opponent | W / L | Result |
| First Round | Andrey Kuznetsov | Win | 6-4, 7-6 (7-4), 6-7 (5-7), 6-2 |
| Second Round | Fernando Verdasco | Win | 6-3, 6-2, 3-6, 6-1 |
| Third Round | Roger Federer | Loss | 3-6, 3-6, 5-7 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Hyeon Chung | Win | 7-6 (7-5), 6-1 |
| Second Round | Grigor Dimitrov | Loss | 6-7 (5-7), 4-6 |
| Coupe Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Hyeon Chung | Loss | 1-6, 6-4, 6-7 (3-7) |
| Abierto Mexicano de Tenis Mifel presentado por Cinemex | ||
| Surface: Hard | Date: Jul. 31 - Aug. 5 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matthew Ebden | Win | 6-4, 6-4 |
| Quarterfinals | Damir Dzumhur | Loss | 7-6 (7-2), 4-6, 6-7 (2-7) |
| J. Safra Sarasin Suisse Open Gstaad | ||
| Surface: Clay | Date: Jul. 24 - Jul. 30 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yannick Hanfmann | Loss | 6-7 (5-7), 6-3, 1-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Adrian Mannarino | Loss | 7-5, 1-6, 1-6, 3-4 Retired |
| AEGON Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Stan Wawrinka | Win | 7-6 (7-4), 7-5 |
| Second Round | Jeremy Chardy | Win | 6-1, 7-6 (7-4) |
| Quarterfinals | Tomas Berdych | Win | 7-6 (7-5), 6-7 (1-7), 7-5 |
| Semifinals | Grigor Dimitrov | Win | 7-5, 3-6, 6-2 |
| Final | Marin Cilic | Win | 4-6, 7-6 (7-2), 7-6 (10-8) |
| MercedesCup | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Gilles Simon | Win | 6-3, 6-3 |
| Second Round | Jeremy Chardy | Win | 6-3, 3-6, 6-2 |
| Quarterfinals | Tomas Berdych | Win | 6-7 (4-7), 6-3, 6-4 |
| Semifinals | Mischa Zverev | Win | 6-7 (2-7), 7-6 (7-4), 7-5 |
| Final | Lucas Pouille | Loss | 6-4, 6-7 (5-7), 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Bjorn Fratangelo | Win | 6-4, 7-6 (7-4), 6-3 |
| Second Round | David Ferrer | Win | 7-5, 3-6, 7-5, 4-6, 6-4 |
| Third Round | Marin Cilic | Loss | 1-6, 3-6, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | David Ferrer | Loss | 6-4, 3-6, 1-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ernesto Escobedo | Win | 6-4, 6-4 |
| Second Round | Gilles Simon | Win | 6-3, 3-6, 7-6 (7-3) |
| Third Round | Novak Djokovic | Loss | 4-6, 5-7 |
| Barcelona Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Albert Montanes | Win | 6-2, 6-2 |
| Third Round | Andy Murray | Loss | 4-6, 4-6 |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 16 - Apr. 23 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Daniil Medvedev | Win | 7-6 (8-6), 7-5 |
| Second Round | Alexander Zverev | Loss | 0-6, 4-6 |
| Fayez Sarofim & Co. US Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 10 - Apr. 16 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bjorn Fratangelo | Win | 7-5, 6-4 |
| Second Round | Hyeon Chung | Win | 4-6, 6-2, 6-1 |
| Quarterfinals | Jack Sock | Loss | 6-7 (6-8), 6-1, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 31 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Malek Jaziri | Loss | 3-6, 6-4, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 30 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dusan Lajovic | Loss | 2-6, 6-4, 6-7 (2-7) |
| Abierto Mexicano TELCEL | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jordan Thompson | Loss | 6-2, 3-6, 3-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Pierre-Hugues Herbert | Loss | 6-7 (5-7), 6-7 (5-7) |
| Open Sud de France | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Julien Benneteau | Win | 6-3, 4-6, 7-6 (7-0) |
| Second Round | Benoit Paire | Loss | 4-6, 6-7 (5-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 28 |
| Round | Opponent | W / L | Result |
| First Round | Fabio Fognini | Loss | 5-7, 3-6, 5-7 |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 2 - Jan. 14 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Michael Venus | Win | 3-6, 6-4, 6-3 |
| Second Round | Jeremy Chardy | Loss | Retired |
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