Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Yadier Molina | Matt Wieters | ||||
| First Base | Paul Goldschmidt | |||||
| Second Base | Kolten Wong | |||||
| Shortstop | Paul DeJong | Yairo Muñoz | ||||
| Third Base | Matt Carpenter | Tommy Edman | ||||
| Left Field | Marcell Ozuna | Lane Thomas | ||||
| Center Field | Dexter Fowler | |||||
| Right Field | Tommy Edman | |||||
| Starting Pitcher | Miles Mikolas | Adam Wainwright | Dakota Hudson | Jack Flaherty | Michael Wacha | |
| Closer | Carlos Martínez | |||||
| Relief Pitcher | Andrew Miller | John Brebbia | John Gant | Tyler Webb | Giovanny Gallegos | Ryan Helsley |
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