Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Yadier Molina | Matt Wieters | ||||
| First Base | Paul Goldschmidt | Rangel Ravelo | ||||
| Second Base | Kolten Wong | |||||
| Shortstop | Paul DeJong | |||||
| Third Base | Matt Carpenter | Brad Miller | ||||
| Left Field | Tommy Edman | Tyler O'Neill | ||||
| Center Field | Harrison Bader | Lane Thomas | ||||
| Right Field | Dexter Fowler | |||||
| Starting Pitcher | Miles Mikolas | Jack Flaherty | Dakota Hudson | Kwang Hyun Kim | Adam Wainwright | |
| Closer | Carlos Martínez | |||||
| Relief Pitcher | Andrew Miller | Giovanny Gallegos | John Gant | Tyler Webb | John Brebbia | Brett Cecil |
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