Transactions
| Date | Player | Transactions |
| 4/17 | Peter Solomon, P | Called Up from Minors |
| 4/17 | Blake Taylor, P | Placed on 10-Day IL (Sprained right ankle) |
| 4/14 | Jose Altuve, 2B | Placed on 10-Day IL (COVID-19 protocol for exposure) |
| 4/14 | Yordan Alvarez, LF | Placed on 10-Day IL (COVID-19 protocol for exposure) |
| 4/14 | Alex Bregman, 3B | Placed on 10-Day IL (COVID-19 protocol for exposure) |
| 4/14 | Ronnie Dawson, LF | Purchased From Minors (selected as Replacement Player) |
| 4/14 | Alex De Goti, 2B | Purchased From Minors (selection as Replacement Player) |
| 4/14 | Robel García, 2B | Placed on 10-Day IL (COVID-19 protocol for exposure) |
| 4/14 | Taylor Jones, 1B | Called Up from Minors |
| 4/14 | Martín Maldonado, C | Placed on 10-Day IL (COVID-19 protocol for exposure) |
| 4/14 | Garrett Stubbs, C | Called Up from Minors |
| 4/14 | Abraham Toro, 3B | Called Up from Minors |
| 4/11 | Jake Odorizzi, P | Called Up from Minors |
| 4/10 | Pedro Báez, P | Removed From 10-Day IL (COVID-19 injured list (positive test)) |
| 4/10 | Pedro Báez, P | Placed on 10-Day IL (Right shoulder soreness) |
| 4/10 | Cristian Javier, P | Sent to Minors |
| 4/10 | Austin Pruitt, P | Transferred to 60-Day IL (Recovery from right elbow surgery) |
| 4/9 | Enoli Paredes, P | Placed on 10-Day IL (Right side soreness) |
| 4/9 | Nivaldo Rodriguez, P | Called Up from Minors |
| 4/1 | Josh James, P | Placed on 10-Day IL (Recovery from left hip surgery) |
| 4/1 | Austin Pruitt, P | Placed on 10-Day IL (Recovery from right elbow surgery) |
| 4/1 | Andre Scrubb, P | Placed on 10-Day IL (Strained right shoulder) |
| 4/1 | Framber Valdez, P | Placed on 10-Day IL (Fractured left ring finger) |
| 3/31 | Kent Emanuel, P | Sent to Minors |
| 3/30 | Jake Odorizzi, P | Sent to Minors |
| 3/30 | Garrett Stubbs, C | Sent to Minors |
| 3/30 | Abraham Toro, 3B | Sent to Minors |
| 3/25 | Steve Cishek, P | Released |
| 3/25 | Taylor Jones, 1B | Sent to Minors |
| 3/25 | Lance McCullers Jr., P | Signed ( 2022-2026)(five-year extension) |
| 3/24 | Steven Souza Jr., RF | Released |
| 3/16 | Tyler Ivey, P | Sent to Minors |
| 3/16 | Freudis Nova, SS | Sent to Minors |
| 3/16 | Jairo Solis, P | Sent to Minors |
| 3/16 | Peter Solomon, P | Sent to Minors |
| 3/12 | Nivaldo Rodriguez, P | Sent to Minors |
| 3/12 | Forrest Whitley, P | Sent to Minors |
| 3/8 | Pedro Báez, P | Placed on 10-Day IL (COVID-19 injured list (positive test)) |
| 3/8 | Jake Odorizzi, P | Signed as Free Agent ( 2021-2022; Opt 2023)(two-year contract) |
| 2/27 | Robel García, 2B | Acquired Off Waivers Los Angeles |
| 2/27 | Justin Verlander, P | Placed on 60-Day IL (Recovery from right elbow surgery) |
| 2/9 | Steve Cishek, P | Signed to a Minor League Contract |
| 2/6 | Carlos Correa, SS | Signed ( 2021)(avoids arbitration) |
| 2/1 | Steven Souza Jr., RF | Signed to a Minor League Contract |
| 1/25 | Michael Brantley, LF | Signed as Free Agent ( 2021-2022)(two-year contract) |
| 1/22 | Humberto Castellanos, P | Designated for Assignment |
| 1/22 | Jason Castro, C | Signed as Free Agent ( 2021-2022)(two-year contract) |
| 1/15 | Pedro Báez, P | Signed as Free Agent ( 2021-2022)(two-year contract) |
| 1/15 | Aledmys Díaz, SS | Signed ( 2021)(avoids arbitration) |
| 1/15 | Lance McCullers Jr., P | Signed ( 2021)(avoids arbitration) |
| 1/8 | Ryne Stanek, P | Signed as Free Agent ( 2021)(one-year contract) |
| 12/4 | Cy Sneed, P | Signed to Play in Japan (Yakult Swallows) |
| 12/3 | Cy Sneed, P | Cleared Waivers and Became a Free Agent |
| 12/2 | Austin Pruitt, P | Signed ( 2021)(avoids arbitration) |
| 12/1 | Cy Sneed, P | Released |
| 11/20 | Tyler Ivey, P | Purchased From Minors |
| 11/20 | Freudis Nova, SS | Purchased From Minors |
| 11/20 | Jairo Solis, P | Purchased From Minors |
| 11/20 | Peter Solomon, P | Purchased From Minors |
| 11/20 | Forrest Whitley, P | Purchased From Minors |
| 11/2 | Dean Deetz, P | Declared Free Agency |
| 11/1 | Bryan Abreu, P | Removed From 60-Day IL (Undisclosed injury) |
| 11/1 | Rogelio Armenteros, P | Removed From 60-Day IL (Bone spur in right elbow) |
| 11/1 | Brooks Raley, P | Signed ( 2021)(team option exercised) |
| 11/1 | Joe Smith, P | Reinstated From Restricted List |
| 11/1 | George Springer, RF | Tendered Qualifying Offer (declined) |
| 10/31 | Yordan Alvarez, LF | Removed From 60-Day IL (Right knee ligament surgery) |
| 10/31 | Austin Pruitt, P | Removed From 60-Day IL (Right elbow soreness) |
| 10/30 | Chase De Jong, P | Outrighted to Minors |
| 10/30 | Chase De Jong, P | Refused Minor League Assignment - Free Agent |
| 10/30 | Chris Devenski, P | Declared Free Agency |
| 10/30 | Dustin Garneau, C | Outrighted to Minors |
| 10/30 | Dustin Garneau, C | Refused Minor League Assignment - Free Agent |
| 10/30 | Roberto Osuna, P | Removed From 60-Day IL (Right elbow soreness) |
| 10/30 | Roberto Osuna, P | Declared Free Agency |
| 10/28 | Michael Brantley, LF | Declared Free Agency |
| 10/28 | Brad Peacock, P | Declared Free Agency |
| 10/28 | Josh Reddick, RF | Declared Free Agency |
| 10/28 | George Springer, RF | Declared Free Agency |
| 10/8 | Joe Biagini, P | Refused Minor League Assignment - Free Agent |
| 10/6 | Joe Biagini, P | Outrighted to Minors |
Last updated Apr. 20, 1:38 A.M. ET
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