Depth Chart
| Position | Starter | 2nd | 3rd | 4th | 5th | 6th |
| Catcher | Jason Castro | Max Stassi | ||||
| First Base | Albert Pujols | |||||
| Second Base | Tommy La Stella | Luís Rengifo | ||||
| Shortstop | Andrelton Simmons | |||||
| Third Base | Anthony Rendon | Matt Thaiss | ||||
| Left Field | Justin Upton | Michael Hermosillo | ||||
| Center Field | Mike Trout | |||||
| Right Field | Brian Goodwin | David Fletcher | ||||
| Designated Hitter | Shohei Ohtani | Jared Walsh | ||||
| Starting Pitcher | Julio Teheran | Andrew Heaney | Dylan Bundy | Griffin Canning | Patrick Sandoval | |
| Closer | Hansel Robles | |||||
| Relief Pitcher | Ty Buttrey | Keynan Middleton | Cam Bedrosian | Noé Ramírez | Luke Bard | Matt Andriese |
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