| Saturday, 11 September 2021 |
| Time/Result | Home | Away | Venue |
| 3-0 |
Crystal Palace |
Tottenham Hotspur | Selhurst Park |
| 1-0 |
Arsenal |
Norwich City | Emirates Stadium |
| 0-1 |
Leicester City |
Manchester City | King Power Stadium |
| 4-1 |
Manchester United |
Newcastle United | Old Trafford |
| 0-0 |
Southampton |
West Ham United | St. Mary's Stadium |
| 0-2 |
Watford |
Wolves | Vicarage Road |
| 0-1 |
Brentford |
Brighton & Hove Albion | Brentford Community Stadium |
| 3-0 |
Chelsea |
Aston Villa | Stamford Bridge |
| Sunday, 12 September 2021 |
| Time/Result | Home | Away | Venue |
| 0-3 |
Leeds United |
Liverpool | Elland Road |
| Monday, 13 September 2021 |
| Time/Result | Home | Away | Venue |
| 3-1 |
Everton |
Burnley | Goodison Park |
| Friday, 17 September 2021 |
| Time/Result | Home | Away | Venue |
| 1-1 |
Newcastle United |
Leeds United | St. James' Park |
| Saturday, 18 September 2021 |
| Time/Result | Home | Away | Venue |
| 0-2 |
Wolves |
Brentford | Molineux Stadium |
| 3-0 |
Liverpool |
Crystal Palace | Anfield |
| 0-0 |
Manchester City |
Southampton | Etihad Stadium |
| 1-3 |
Norwich City |
Watford | Carrow Road |
| 0-1 |
Burnley |
Arsenal | Turf Moor |
| 3-0 |
Aston Villa |
Everton | Villa Park |
| Sunday, 19 September 2021 |
| Time/Result | Home | Away | Venue |
| 6:00 AM PT7:00 AM MT8:00 AM CT9:00 AM ET13:00 GMT14:00 13:00 1:00 PM 15:00 KSA12:00 AM AET18:30 IST8:30 AM VEN17:00 UAE9:00 PM SST21:00 20:00 6:00 AM MST7:00 AM CST8:00 AM EST9:00 ET8:00 10:00 BRT9:00 8:00 AM CT |
West Ham United |
Manchester United | London Stadium |
| 6:00 AM PT7:00 AM MT8:00 AM CT9:00 AM ET13:00 GMT14:00 13:00 1:00 PM 15:00 KSA12:00 AM AET18:30 IST8:30 AM VEN17:00 UAE9:00 PM SST21:00 20:00 6:00 AM MST7:00 AM CST8:00 AM EST9:00 ET8:00 10:00 BRT9:00 8:00 AM CT |
Brighton & Hove Albion |
Leicester City | The American Express Community Stadium |
| 8:30 AM PT9:30 AM MT10:30 AM CT11:30 AM ET15:30 GMT16:30 15:30 3:30 PM 17:30 KSA2:30 AM AET21:00 IST11:00 AM VEN19:30 UAE11:30 PM SST23:30 22:30 8:30 AM MST9:30 AM CST10:30 AM EST11:30 ET10:30 12:30 BRT11:30 10:30 AM CT |
Tottenham Hotspur |
Chelsea | Tottenham Hotspur Stadium |
| Saturday, 25 September 2021 |
| Time/Result | Home | Away | Venue |
| 4:30 AM PT5:30 AM MT6:30 AM CT7:30 AM ET11:30 GMT12:30 11:30 11:30 AM 13:30 KSA10:30 PM AET17:00 IST7:00 AM VEN15:30 UAE7:30 PM SST19:30 18:30 4:30 AM MST5:30 AM CST6:30 AM EST7:30 ET6:30 8:30 BRT7:30 6:30 AM CT |
Chelsea |
Manchester City | Stamford Bridge |
| 4:30 AM PT5:30 AM MT6:30 AM CT7:30 AM ET11:30 GMT12:30 11:30 11:30 AM 13:30 KSA10:30 PM AET17:00 IST7:00 AM VEN15:30 UAE7:30 PM SST19:30 18:30 4:30 AM MST5:30 AM CST6:30 AM EST7:30 ET6:30 8:30 BRT7:30 6:30 AM CT |
Manchester United |
Aston Villa | Old Trafford |
| 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT15:00 14:00 2:00 PM 16:00 KSA1:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT |
Everton |
Norwich City | Goodison Park |
| 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT15:00 14:00 2:00 PM 16:00 KSA1:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT |
Leeds United |
West Ham United | Elland Road |
| 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT15:00 14:00 2:00 PM 16:00 KSA1:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT |
Leicester City |
Burnley | King Power Stadium |
| 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT15:00 14:00 2:00 PM 16:00 KSA1:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT |
Watford |
Newcastle United | Vicarage Road |
| 9:30 AM PT10:30 AM MT11:30 AM CT12:30 PM ET16:30 GMT17:30 16:30 4:30 PM 18:30 KSA3:30 AM AET22:00 IST12:00 PM VEN20:30 UAE12:30 AM SST0:30 23:30 9:30 AM MST10:30 AM CST11:30 AM EST12:30 ET11:30 13:30 BRT12:30 11:30 AM CT |
Brentford |
Liverpool | Brentford Community Stadium |
| Sunday, 26 September 2021 |
| Time/Result | Home | Away | Venue |
| 6:00 AM PT7:00 AM MT8:00 AM CT9:00 AM ET13:00 GMT14:00 13:00 1:00 PM 15:00 KSA12:00 AM AET18:30 IST8:30 AM VEN17:00 UAE9:00 PM SST21:00 20:00 6:00 AM MST7:00 AM CST8:00 AM EST9:00 ET8:00 10:00 BRT9:00 8:00 AM CT |
Southampton |
Wolves | St. Mary's Stadium |
| 8:30 AM PT9:30 AM MT10:30 AM CT11:30 AM ET15:30 GMT16:30 15:30 3:30 PM 17:30 KSA2:30 AM AET21:00 IST11:00 AM VEN19:30 UAE11:30 PM SST23:30 22:30 8:30 AM MST9:30 AM CST10:30 AM EST11:30 ET10:30 12:30 BRT11:30 10:30 AM CT |
Arsenal |
Tottenham Hotspur | Emirates Stadium |
| Monday, 27 September 2021 |
| Time/Result | Home | Away | Venue |
| 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET19:00 GMT20:00 19:00 7:00 PM 21:00 KSA6:00 AM AET0:30 (+1) IST2:30 PM VEN23:00 UAE3:00 AM SST3:00 2:00 12:00 PM MST1:00 PM CST2:00 PM EST15:00 ET14:00 16:00 BRT15:00 2:00 PM CT |
Crystal Palace |
Brighton & Hove Albion | Selhurst Park |
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